比较患有和未患有子痫前期的产妇的脐带血中 CD4+CD25+FOXP3+、CD4+CD25+FOXP3+和 CD4+FOXP3+Treg 的百分比。
Comparison of the percentages of CD4 CD25 FOXP3 , CD4 CD25 FOXP3 , and CD4 FOXP3 Tregs, in the umbilical cord blood of babies born to mothers with and without preeclampsia.
机构信息
Clinical and Chemical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Clinical and Chemical Pathology Department, Faculty of Medicine, Benha University, Benha, Egypt.
出版信息
Am J Reprod Immunol. 2017 Dec;78(6). doi: 10.1111/aji.12761. Epub 2017 Sep 16.
PROBLEM
Little is known about how preeclampsia affects regulatory T-cell count and functions in umbilical cord blood of babies born to preeclamptic mothers. Here, we analyze the percentage of CD4 CD25 FOXP3 , CD4 CD25 FOXP3 , and CD4 FOXP3 Tregs, in the umbilical cord blood of babies born to mothers with and without preeclampsia.
METHOD OF STUDY
The percentage of umbilical cord blood CD4 CD25 FOXP3 , CD4 CD25 FOXP3 , and CD4 FOXP3 Tregs were analyzed by flow cytometry.
RESULTS
CD4 CD25 FOXP3 Treg (%) and CD4 FOXP3 Treg (%) were significantly lower, while CD4 CD25 (%) was significantly higher in umbilical cord blood of babies born to preeclamptic mothers.
CONCLUSION
Preeclampsia is associated with immune dysregulation which leads to a deficiency in Treg (CD4 CD25 FOXP3 ) in the umbilical cord blood of babies born to preeclamptic mothers.
问题
关于子痫前期如何影响子痫前期母亲所生婴儿脐带血中调节性 T 细胞的数量和功能，目前知之甚少。在这里，我们分析了患有和未患有子痫前期的母亲所生婴儿脐带血中 CD4+CD25+FOXP3+、CD4+CD25+FOXP3 和 CD4+FOXP3 Treg 的百分比。
研究方法
通过流式细胞术分析脐带血中 CD4+CD25+FOXP3+、CD4+CD25+FOXP3 和 CD4+FOXP3 Treg 的百分比。
结果
患有子痫前期母亲所生婴儿的脐带血中 CD4+CD25+FOXP3+Treg（%）和 CD4+FOXP3+Treg（%）显著降低，而 CD4+CD25（%）显著升高。
结论
子痫前期与免疫失调有关，导致子痫前期母亲所生婴儿脐带血中 Treg（CD4+CD25+FOXP3+）缺乏。
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