CSIR-Central Salt and Marine Chemicals Research Institute , Bhavnagar 364002, India.
Langmuir. 2017 Oct 17;33(41):10989-10999. doi: 10.1021/acs.langmuir.7b02777. Epub 2017 Oct 5.
A unique fluorescence resonance energy transfer (FRET) process is found to be operational in a unilamellar lipid self-assembly in the aqueous phase. A newly synthesized naphthyl based long chain lipid derivative [N-(naphthalene-1-ylmethyl)tetradecane-1-ammonium chloride, 14NA] forms various self-assembled architectures in the aqueous phase. Controlled changes in lipid concentration lead to a transition of the self-assemblies from micelles to vesicles to rods. In the presence of cucurbit[7]uril (CB7), 14NA forms a host-guest [2]pseudorotaxane complex (CB7∋14NA) and secondary interactions lead to the formation of a lipid bilayer with hydrophobic pockets situated in between the layers. The change in the structure of 14NA assemblies, interaction with CB7 and formation of supramolecular assemblies of CB7∋14NA were examined using light scattering, spectroscopic, and microscopic techniques. Entrapment of a luminescent dye, anthracene within the hydrophobic bilayer of the supramolecular assembly CB7∋14NA favors a modified luminescent response due to an efficient FRET process. Further, the FRET process could be controlled by thermal and chemical stimuli that induce transformation of unilamellar vesicles.
在水相中单分子层脂质自组装中发现了一种独特的荧光共振能量转移（FRET）过程。一种新合成的基于萘基的长链脂质衍生物[N-（萘-1-基甲基）十四烷-1-铵氯化物，14NA]在水相中形成各种自组装结构。控制脂质浓度的变化导致自组装从胶束到囊泡再到棒状结构的转变。在葫芦[7]脲（CB7）存在下，14NA 形成主客体[2]假轮烷配合物（CB7∋14NA），二级相互作用导致形成具有位于层之间的疏水口袋的脂质双层。使用光散射、光谱和显微镜技术研究了 14NA 组装体的结构变化、与 CB7 的相互作用以及 CB7∋14NA 的超分子组装的形成。将发光染料蒽烯包埋在超分子组装 CB7∋14NA 的疏水双层中，由于有效的 FRET 过程，有利于修饰后的发光响应。此外，FRET 过程可以通过热和化学刺激来控制，这些刺激可以诱导单分子层囊泡的转化。
