Holmes Michael V, Pulit Sara L, Lindgren Cecilia M
Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, UK.
Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Genome Med. 2017 Sep 18;9(1):82. doi: 10.1186/s13073-017-0474-5.
Over 300 million adults are obese, but little is known about the impact of obesity on cardiovascular health. We discuss recent genetic and epigenetic studies of adiposity that indicate a causal role for general and central adiposity in cardiometabolic disease, and highlight potential mechanisms including insulin resistance and gene expression.
超过3亿成年人肥胖，但肥胖对心血管健康的影响却鲜为人知。我们讨论了近期关于肥胖的遗传和表观遗传学研究，这些研究表明总体肥胖和中心性肥胖在心脏代谢疾病中起因果作用，并强调了包括胰岛素抵抗和基因表达在内的潜在机制。
