软组织肉瘤的随机对照试验：我们正在取得进展！

Randomized Controlled Trials in Soft Tissue Sarcoma: We Are Getting There!

作者信息

MacNeill Andrea J, Gupta Abha, Swallow Carol J

机构信息

Division of Surgical Oncology, Department of Surgery, Diamond Health Care Centre, BC Cancer Agency, University of British Columbia, 5199-2775 Laurel Street, Vancouver, British Columbia V5Z 1M9, Canada.

Department of Hematology/Oncology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada; Department of Medical Oncology, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada.

出版信息

Surg Oncol Clin N Am. 2017 Oct;26(4):531-544. doi: 10.1016/j.soc.2017.05.001. Epub 2017 Aug 4.

DOI:10.1016/j.soc.2017.05.001

PMID:28923218

Abstract

Soft tissue sarcoma (STS) is a family of malignancies for which individual management decisions can be complex. There is a paucity of level 1 evidence, as the rarity and heterogeneity of STS pose challenges to the design and execution of randomized controlled trials. Radiotherapy (RT) is routinely used to facilitate function-preserving surgery and to improve local control. Delivery of RT in the preoperative setting can decrease chronic toxicities at the cost of increased wound complications in the short-term. The role of adjuvant systemic therapies remains controversial in adult STS.

摘要

软组织肉瘤（STS）是一类恶性肿瘤，针对其进行个体治疗决策可能很复杂。一级证据匮乏，因为STS的罕见性和异质性给随机对照试验的设计和实施带来了挑战。放射治疗（RT）通常用于辅助进行保留功能的手术并改善局部控制。术前进行RT可降低慢性毒性，但短期内会增加伤口并发症的风险。辅助性全身治疗在成人STS中的作用仍存在争议。