Nikaido Masataka, Navajas Acedo Joaquin, Hatta Kohei, Piotrowski Tatjana
Stowers Institute for Medical Research, Kansas City, MO 64110, USA; Graduate School of Life Sciences, University of Hyogo, Hyogo Pref. 678-1297, Japan.
Stowers Institute for Medical Research, Kansas City, MO 64110, USA.
Dev Biol. 2017 Nov 15;431(2):215-225. doi: 10.1016/j.ydbio.2017.09.017. Epub 2017 Sep 18.
The lateral line system is a mechanosensory systems present in aquatic animals. The anterior and posterior lateral lines develop from anterior and posterior lateral line placodes (aLLp and pLLp), respectively. Although signaling molecules required for the induction of other cranial placodes have been well studied, the molecular mechanisms underlying formation of the lateral line placodes are unknown. In this study we tested the requirement of multiple signaling pathways, such as Wnt, Bmp Fgf, and Retinoic Acid for aLLp and pLLp induction. We determined that aLLp specification requires Fgf signaling, whilst pLLp specification requires retinoic acid which inhibits Fgf signaling. pLLp induction is also independent of Wnt and Bmp activities, even though these pathways limit the boundaries of the pLLp. This is the first report that the aLLp and pLLp depend on different inductive mechanisms and that pLLp induction requires the inhibition of Fgf, Wnt and Bmp signaling.
侧线系统是水生动物所具有的一种机械感觉系统。前侧线和后侧线分别从前侧线基板（aLLp）和后侧线基板（pLLp）发育而来。尽管诱导其他颅基板所需的信号分子已得到充分研究，但侧线基板形成的分子机制尚不清楚。在本研究中，我们测试了多种信号通路，如Wnt、Bmp、Fgf和视黄酸对aLLp和pLLp诱导的需求。我们确定aLLp的特化需要Fgf信号，而pLLp的特化需要抑制Fgf信号的视黄酸。pLLp的诱导也独立于Wnt和Bmp活性，尽管这些信号通路限制了pLLp的边界。这是第一份关于aLLp和pLLp依赖不同诱导机制且pLLp诱导需要抑制Fgf、Wnt和Bmp信号的报告。
