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解析渐渗的基因组景观。

Interpreting the genomic landscape of introgression.

机构信息

Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, United Kingdom.

Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, United Kingdom.

出版信息

Curr Opin Genet Dev. 2017 Dec;47:69-74. doi: 10.1016/j.gde.2017.08.007. Epub 2017 Sep 17.

Abstract

Introgression, the transfer of genetic material between species through hybridisation, occurs in many taxa and has important consequences. Genomic studies allow us to characterise the landscape of introgression across the genome, shedding light on both its adaptive benefits and the incompatibilities that help to maintain species barriers. Studies taking a genome-wide view suggest that adaptive introgression may be common, but that introgressed variation between many species is selected against throughout much of the genome. Confounding factors can complicate interpretations from these data, and computational simulations have proved vital to illustrate expected patterns under different scenarios. Future developments will move beyond correlative evidence to explicit models that account for how selection and genetic drift influence introgressed variation.

摘要

渐渗杂交,即通过杂交在物种间转移遗传物质的现象,发生在许多类群中,并具有重要的后果。基因组研究使我们能够描述整个基因组中渐渗的情况,揭示其适应性益处以及有助于维持物种障碍的不兼容性。从全基因组角度进行的研究表明,适应性渐渗可能很常见,但在许多物种之间,渐渗的变异在整个基因组的大部分区域都受到选择的抑制。混淆因素会使这些数据的解释变得复杂,计算模拟已被证明对于说明不同情况下预期模式至关重要。未来的发展将超越相关证据,建立明确的模型,说明选择和遗传漂变如何影响渐渗的变异。

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