印度人群的血清前列腺特异性抗原水平：有差异吗？
Serum PSA levels in the Indian population: Is it different?
作者信息
Agrawal Amit, Karan Shailesh Chandra
机构信息
Classified Specialist (Surgery) & Urologist, Command Hospital (Southern Command), Pune 411040, India.
Consultant (Urology & Renal Transplant), Columbia Asia Hospital, Ghaziabad, UP, India.
出版信息
Med J Armed Forces India. 2017 Apr;73(2):112-117. doi: 10.1016/j.mjafi.2016.10.004. Epub 2016 Nov 30.
BACKGROUND
Serum prostate-specific antigen (PSA) is an important tumour, marker which is widely used to trigger trans-rectal ultrasound (TRUS)-guided prostate biopsy. However, the PSA levels vary with race and ethnicity. Therefore, there is a need to have an Indian reference range.
METHODS
All adult male patients meeting the inclusion and exclusion criteria were enrolled in this study. They were subjected to assessment of serum total PSA, digital rectal examination and trans-abdominal ultrasound. If any one or more of these were found abnormal, then a TRUS-guided 12-core prostate biopsy was done. Patients who were detected to have prostatic cancer were excluded from the final analysis. The data so obtained was grouped among the following three age groups: 40-49, 50-59 and 60-70 years, and the age-specific PSA values, prostatic volume and PSA density were found.
RESULTS
A total of 1772 patients were analysed. The mean serum total PSA was 1.76 ng/ml with a standard deviation of 2.566 ng/ml. Group-wise age distribution of the mean serum total PSA was 1.22, 1.97 and 2.08 ng/ml in 40-49, 50-59 and 60-70 years age groups.
CONCLUSION
The mean total PSA and the age-specific PSA range tend to be lower in the Indians than the Western population.
背景
血清前列腺特异性抗原（PSA）是一种重要的肿瘤标志物，广泛用于触发经直肠超声（TRUS）引导下的前列腺活检。然而，PSA水平因种族和民族而异。因此，需要有一个印度人的参考范围。
方法
所有符合纳入和排除标准的成年男性患者均纳入本研究。他们接受了血清总PSA评估、直肠指检和经腹超声检查。如果发现其中任何一项或多项异常，则进行TRUS引导下的12针前列腺活检。被检测出患有前列腺癌的患者被排除在最终分析之外。将所获得的数据分为以下三个年龄组：40 - 49岁、50 - 59岁和60 - 70岁，并得出各年龄组的PSA值、前列腺体积和PSA密度。
结果
共分析了1772例患者。血清总PSA的平均值为1.76 ng/ml，标准差为2.566 ng/ml。40 - 49岁、50 - 59岁和60 - 70岁年龄组的血清总PSA平均年龄分布分别为1.22、1.97和2.08 ng/ml。
结论
印度人的总PSA平均值和各年龄组的PSA范围往往低于西方人群。
Zotero 插件