Ganpule Arvind P, Desai Mahesh R, Manohar T, Bapat Sharad
Department of Urology, Muljibhai Patel Urological Hospital, Dr. V. V. Desai Road, Nadiad, Gujarat, India.
Indian J Urol. 2007 Apr;23(2):122-5. doi: 10.4103/0970-1591.32060.
We sought to determine the distribution of serum prostate specific antigen (PSA) levels in a community-based population in the state of Gujarat in India.
Community screening of subjects residing in Kheda and Anand districts of Gujarat was done with digital rectal examination (DRE), uroflowmetry and transabdominal sonography and serum PSA. In three villages transrectal sonography was done in addition to transabdominal sonography. All patients with a PSA of more than 4 ng/ml and / or abnormal DRE were evaluated. Biopsy-proven prostatic malignancy was detected in 20 patients. Subjects who did not follow up and who had biopsy-proven malignancy were excluded from the analysis, 1899 subjects were analyzed.
One thousand seven hundred and eighty-seven (89.17%) had a PSA of <4 ngml, 180 (8.9%) had a PSA between 4-10 ng/ml, while 37 (1.8 %) had a PSA more than 10ng/ml. There was a statistically significant correlation between age and prostate volume (correlation coefficient 0.33) and between prostate volume and PSA (correlation coefficient 0.50). The age-specific PSA values derived as the 95(th) percentile value were as follows, 40-49 years (0-2.1), 50-59 years (0-3.4), 60-69 years (0-4.2) and more than 70 years (0-5.0). The 95(th) percentile value for PSAD was 0.19.
Indians need to have separate PSA reference ranges. The age-specific PSA ranges for men in the present study population are on the lower side and the prostate specific antigen density on the higher side.
我们试图确定印度古吉拉特邦一个社区人群的血清前列腺特异性抗原（PSA）水平分布情况。
对居住在古吉拉特邦凯达和阿南德地区的受试者进行社区筛查，检查项目包括直肠指诊（DRE）、尿流率测定、经腹超声检查以及血清PSA检测。在三个村庄，除经腹超声检查外还进行了经直肠超声检查。对所有PSA大于4 ng/ml和/或直肠指诊异常的患者进行评估。经活检证实有前列腺恶性肿瘤的患者共20例。未进行随访以及经活检证实有恶性肿瘤的受试者被排除在分析之外，最终对1899名受试者进行了分析。
1787名（89.17%）受试者的PSA<4 ng/ml，180名（8.9%）受试者的PSA在4 - 10 ng/ml之间，而37名（1.8%）受试者的PSA大于10 ng/ml。年龄与前列腺体积之间（相关系数0.33）以及前列腺体积与PSA之间（相关系数0.50）存在统计学显著相关性。以第95百分位数得出的年龄特异性PSA值如下：40 - 49岁（0 - 2.1），50 - 59岁（0 - 3.4），60 - 69岁（0 - 4.2）以及70岁以上（0 - 5.0）。PSAD的第95百分位数为0.19。
印度人需要有单独的PSA参考范围。本研究人群中男性的年龄特异性PSA范围较低，而前列腺特异性抗原密度较高。
