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Amyloid beta-protein gene duplication is not common in Alzheimer's disease: analysis by polymorphic restriction fragments.

作者信息

Furuya H, Sasaki H, Goto I, Wong C W, Glenner G G, Sakaki Y

机构信息

Research Laboratory for Genetic Information, Kyushu University, Fukuoka, Japan.

出版信息

Biochem Biophys Res Commun. 1988 Jan 15;150(1):75-81. doi: 10.1016/0006-291x(88)90488-3.

Abstract

The amyloid beta-protein(BP) is an important component of amyloid fibrils of both Alzheimer's disease(AD) and adult Down syndrome(DS). It has been hypothesized that sporadic AD may involve the duplication of a subregion of chromosome 21 containing the BP locus. However, an improved method for detection of the BP gene duplication using polymorphic Hind III fragments led us to a conclusion that BP gene duplication is rare, if any, in (Japanese) sporadic AD patients, indicating that the duplication of the BP gene itself is not the common underlying genetic defect in AD.

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