Furuya H, Sasaki H, Goto I, Wong C W, Glenner G G, Sakaki Y
Research Laboratory for Genetic Information, Kyushu University, Fukuoka, Japan.
Biochem Biophys Res Commun. 1988 Jan 15;150(1):75-81. doi: 10.1016/0006-291x(88)90488-3.
The amyloid beta-protein(BP) is an important component of amyloid fibrils of both Alzheimer's disease(AD) and adult Down syndrome(DS). It has been hypothesized that sporadic AD may involve the duplication of a subregion of chromosome 21 containing the BP locus. However, an improved method for detection of the BP gene duplication using polymorphic Hind III fragments led us to a conclusion that BP gene duplication is rare, if any, in (Japanese) sporadic AD patients, indicating that the duplication of the BP gene itself is not the common underlying genetic defect in AD.