Chiu Ada W, Stenstrom Robert
1 Department of Pharmacy, Peace Arch Hospital, White Rock, British Columbia, Canada.
2 Department of Emergency Medicine, Peace Arch Hospital, White Rock, British Columbia, Canada.
J Pharm Pract. 2017 Jan 1:897190017731246. doi: 10.1177/0897190017731246.
Tadalafil is a drug approved for use in erectile dysfunction, but increasingly being used recreationally. There have only been scant case reports on tadalafil causing fixed drug eruption (FDE). Patients who use tadalafil recreationally are less likely to seek medical attention and the diagnosis can often be missed, given the difficulty in diagnosis. However, clinical examination together with a detailed medication history can provide clinicians with good evidence of the association without invasive biopsies. We discuss a 37-year-old male who developed FDE after 2 separate exposures to tadalafil used for recreational purpose. The scar from the first reaction served as a landmark for the second exposure. His lesions resolved 2 days after the initial presentation. The Naranjo adverse drug reaction probability scale (score = 9) indicates a definite adverse drug reaction to tadalafil. We hope to raise awareness of this drug reaction with this case report.
他达拉非是一种被批准用于治疗勃起功能障碍的药物，但越来越多地被用于娱乐目的。关于他达拉非引起固定性药疹（FDE）的病例报告很少。娱乐性使用他达拉非的患者不太可能寻求医疗帮助，而且由于诊断困难，诊断往往会被漏诊。然而，临床检查和详细的用药史可以为临床医生提供关联性的有力证据，而无需进行侵入性活检。我们讨论了一名37岁男性，他在两次分别娱乐性使用他达拉非后出现了固定性药疹。第一次反应留下的疤痕成为第二次接触的标志。他的皮疹在初次出现后2天消退。纳兰霍药物不良反应概率量表（评分=9）表明对他达拉非有明确的药物不良反应。我们希望通过这个病例报告提高对这种药物反应的认识。
