Giral P, Martin P, Soubrié P, Simon P
Faculté de Médecine Pitié-Salpêtrière, Paris, France.
Biol Psychiatry. 1988 Feb 1;23(3):237-42. doi: 10.1016/0006-3223(88)90034-0.
This study is designed to measure effects of serotonin 1A (5-HT1A) agonists on escape deficits produced by inescapable shock in rats--a model of learned helplessness. Rats were first exposed to 60 inescapable shocks (15-sec duration, 0.8 mA, every 1 min +/- 15 sec), and 48 hr later, they were subjected to daily 15-min shuttle-box sessions (30 trials/day) on 3 consecutive days. Twice daily intraperitoneal injection of buspirone (total daily dose of 0.5 and 1 mg/kg), gepirone (0.06 and 0.125 mg/kg), 8-OH dipropylamino-tetralin (8-OH-DPAT) (0.03, 0.06, 0.125, and 0.25 mg/kg), and ipsapirone (TVXQ 7821) (0.03 and 0.06 mg/kg) eliminated escape failures. This indicates that an antidepressant-like effect--reversal of helpless behavior--can be obtained with drugs assumed to stimulate serotonin 1A receptors.
本研究旨在测量血清素1A（5-HT1A）激动剂对大鼠不可逃避电击所产生的逃避缺陷的影响——一种习得性无助模型。大鼠首先接受60次不可逃避电击（持续15秒，0.8毫安，每1分钟±15秒），48小时后，连续3天每天进行15分钟的穿梭箱实验（每天30次试验）。每天两次腹腔注射丁螺环酮（每日总剂量0.5和1毫克/千克）、吉哌隆（0.06和0.125毫克/千克）、8-羟基二丙基氨基四氢萘（8-OH-DPAT）（0.03、0.06、0.125和0.25毫克/千克）以及伊沙匹隆（TVXQ 7821）（0.03和0.06毫克/千克）可消除逃避失败。这表明，使用假定能刺激血清素1A受体的药物可获得类似抗抑郁的效果——逆转无助行为。
