Gilbert F, Dourish C T
Merck Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, UK.
Psychopharmacology (Berl). 1987;93(3):349-52. doi: 10.1007/BF00187255.
The effects of the novel anxiolytics gepirone, buspirone and ipsapirone on free feeding and on feeding induced by the 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), were examined. Gepirone dose-dependently increased feeding 2 and 4 h after injection, the magnitude of the response being larger than previously observed with any other 5-HT1A receptor ligand. Previous studies have suggested that buspirone and ipsapirone can block some of the behavioural effects of 8-OH-DPAT. However, gepirone, buspirone and ipsapirone did not inhibit feeding induced by 8-OH-DPAT. These results indicate that gepirone is a very efficacious appetite stimulant in rats and suggest that gepirone, buspirone and ipsapirone act as 5-HT autoreceptor agonists in the feeding model.
研究了新型抗焦虑药吉哌隆、丁螺环酮和伊沙匹隆对自由进食以及5-羟色胺1A受体激动剂8-羟基-2-（二正丙基氨基）四氢萘（8-OH-DPAT）诱导进食的影响。注射后2小时和4小时，吉哌隆使进食量呈剂量依赖性增加，反应幅度大于先前使用任何其他5-羟色胺1A受体配体时观察到的情况。先前的研究表明，丁螺环酮和伊沙匹隆可阻断8-OH-DPAT的某些行为效应。然而，吉哌隆、丁螺环酮和伊沙匹隆并未抑制8-OH-DPAT诱导的进食。这些结果表明，吉哌隆是大鼠中一种非常有效的食欲刺激剂，并提示在进食模型中，吉哌隆、丁螺环酮和伊沙匹隆作为5-羟色胺自身受体激动剂发挥作用。
