新型抗焦虑药吉哌隆、丁螺环酮和伊沙匹隆对自由进食及8-羟基二丙胺诱发进食的影响。

Effects of the novel anxiolytics gepirone, buspirone and ipsapirone on free feeding and on feeding induced by 8-OH-DPAT.

作者信息

Gilbert F, Dourish C T

机构信息

Merck Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, UK.

出版信息

Psychopharmacology (Berl). 1987;93(3):349-52. doi: 10.1007/BF00187255.

DOI:10.1007/BF00187255

PMID:2893412

Abstract

The effects of the novel anxiolytics gepirone, buspirone and ipsapirone on free feeding and on feeding induced by the 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), were examined. Gepirone dose-dependently increased feeding 2 and 4 h after injection, the magnitude of the response being larger than previously observed with any other 5-HT1A receptor ligand. Previous studies have suggested that buspirone and ipsapirone can block some of the behavioural effects of 8-OH-DPAT. However, gepirone, buspirone and ipsapirone did not inhibit feeding induced by 8-OH-DPAT. These results indicate that gepirone is a very efficacious appetite stimulant in rats and suggest that gepirone, buspirone and ipsapirone act as 5-HT autoreceptor agonists in the feeding model.

摘要

研究了新型抗焦虑药吉哌隆、丁螺环酮和伊沙匹隆对自由进食以及5-羟色胺1A受体激动剂8-羟基-2-（二正丙基氨基）四氢萘（8-OH-DPAT）诱导进食的影响。注射后2小时和4小时，吉哌隆使进食量呈剂量依赖性增加，反应幅度大于先前使用任何其他5-羟色胺1A受体配体时观察到的情况。先前的研究表明，丁螺环酮和伊沙匹隆可阻断8-OH-DPAT的某些行为效应。然而，吉哌隆、丁螺环酮和伊沙匹隆并未抑制8-OH-DPAT诱导的进食。这些结果表明，吉哌隆是大鼠中一种非常有效的食欲刺激剂，并提示在进食模型中，吉哌隆、丁螺环酮和伊沙匹隆作为5-羟色胺自身受体激动剂发挥作用。

相似文献

Effects of the novel anxiolytics gepirone, buspirone and ipsapirone on free feeding and on feeding induced by 8-OH-DPAT.

Psychopharmacology (Berl). 1987;93(3):349-52. doi: 10.1007/BF00187255.

Relationship of increased food intake and plasma ACTH levels to 5-HT1A receptor activation in rats.

Psychoneuroendocrinology. 1988;13(6):471-8. doi: 10.1016/0306-4530(88)90032-7.

Buspirone, 8-OH-DPAT and ipsapirone: effects on hippocampal cerebellar and sciatic fiber excitability.

Brain Res. 1988 Sep 27;461(1):1-9. doi: 10.1016/0006-8993(88)90719-6.

The involvement of 5-hydroxytryptaminergic and dopaminergic mechanisms in the eating induced by buspirone, gepirone and ipsapirone.

Br J Pharmacol. 1990 Mar;99(3):519-25. doi: 10.1111/j.1476-5381.1990.tb12961.x.

Receptor reserve for 5-hydroxytryptamine1A-mediated inhibition of serotonin synthesis: possible relationship to anxiolytic properties of 5-hydroxytryptamine1A agonists.

Mol Pharmacol. 1990 Feb;37(2):231-7.

Reversal of helpless behavior in rats by putative 5-HT1A agonists.

Biol Psychiatry. 1988 Feb 1;23(3):237-42. doi: 10.1016/0006-3223(88)90034-0.

Effects of buspirone differ from those of gepirone and 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) on unpunished responding of pigeons.

Pharmacol Biochem Behav. 1988 Jul;30(3):723-7. doi: 10.1016/0091-3057(88)90090-1.

Neuronal circuits involved in the anxiolytic effects of the 5-HT1A receptor agonists 8-OH-DPAT ipsapirone and buspirone in the rat.

Eur J Pharmacol. 1993 Nov 16;249(3):341-51. doi: 10.1016/0014-2999(93)90531-l.

Response of cerebellar Purkinje cells to serotonin and the 5-HT1A agonists 8-OH-DPAT and ipsapirone in vitro.

Eur J Pharmacol. 1990 Jan 10;175(2):145-53. doi: 10.1016/0014-2999(90)90225-u.

Effects of 5-HT1A receptor agonists and L-5-HTP in Montgomery's conflict test.

Pharmacol Biochem Behav. 1989 Jan;32(1):259-65. doi: 10.1016/0091-3057(89)90242-6.

引用本文的文献

International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function.

Pharmacol Rev. 2021 Jan;73(1):310-520. doi: 10.1124/pr.118.015552.

Agmatine in the hypothalamic paraventricular nucleus stimulates feeding in rats: involvement of neuropeptide Y.

Br J Pharmacol. 2011 Sep;164(2b):704-18. doi: 10.1111/j.1476-5381.2011.01484.x.

Investigating the motivational mechanism of altered saline consumption following 5-HT(1A) manipulation.

Behav Neurosci. 2008 Apr;122(2):407-15. doi: 10.1037/0735-7044.122.2.407.

Molecular signaling involved in regulating feeding and other motivated behaviors.

Mol Neurobiol. 2007 Feb;35(1):1-20. doi: 10.1007/BF02700621.

Effects of 8-OH-DPAT and WAY-100635 on performance on a time-constrained progressive-ratio schedule.

Psychopharmacology (Berl). 2003 May;167(2):137-44. doi: 10.1007/s00213-002-1375-9. Epub 2003 Mar 25.

Behavioural evidence that d-fenfluramine-induced anorexia in the rat is not mediated by the 5-HT1A receptor subtype.

Psychopharmacology (Berl). 1996 May;125(2):168-75. doi: 10.1007/BF02249416.

Mediation of the antidepressant-like effect of 8-OH-DPAT in mice by postsynaptic 5-HT1A receptors.

Br J Pharmacol. 1993 Mar;108(3):669-77. doi: 10.1111/j.1476-5381.1993.tb12859.x.

5-HT1A receptor agonists improve the performance of normal and scopolamine-impaired rats in an operant delayed matching to position task.

Psychopharmacology (Berl). 1994 Oct;116(2):135-42. doi: 10.1007/BF02245055.

8-OH-DPAT elicits feeding and not chewing: evidence from liquid diet studies and a diet choice test.

Psychopharmacology (Berl). 1988;95(2):185-8. doi: 10.1007/BF00174507.

8-OH-DPAT specifically enhances feeding behaviour in mice: evidence from behavioural competition.

Psychopharmacology (Berl). 1990;101(3):408-13. doi: 10.1007/BF02244062.

本文引用的文献

Brain serotonin receptors as a target for the putative anxiolytic TVX Q 7821.

Brain Res Bull. 1984 Jun;12(6):741-4. doi: 10.1016/0361-9230(84)90155-2.

8-Hydroxy-2-(di-n-propylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist.

J Med Chem. 1981 Aug;24(8):921-3. doi: 10.1021/jm00140a002.

Electrophysiologically-identified serotonin receptors in the rat CNS. Effect of antidepressant treatment.

Neuropharmacology. 1984 Dec;23(12B):1511-20. doi: 10.1016/0028-3908(84)90095-9.

The involvement of subtypes of the 5-HT1 receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-propylamino)tetralin in the rat.

Eur J Pharmacol. 1984 Nov 13;106(2):271-82. doi: 10.1016/0014-2999(84)90714-3.

8-Hydroxy-2-(di-n-propylamino) tetralin is devoid of activity at the 5-hydroxytryptamine autoreceptor in rat brain. Implications for the proposed link between the autoreceptor and the [3H] 5-HT recognition site.

Naunyn Schmiedebergs Arch Pharmacol. 1984 Aug;327(1):18-22. doi: 10.1007/BF00504986.

8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site.

Eur J Pharmacol. 1983 May 20;90(1):151-3. doi: 10.1016/0014-2999(83)90230-3.

Comparative neuropharmacology of buspirone and MJ-13805, a potential anti-anxiety drug.

J Neural Transm. 1983;57(4):255-65. doi: 10.1007/BF01248997.

Dopamine and antianxiety activity.

Pharmacol Biochem Behav. 1982;17 Suppl 1:25-35. doi: 10.1016/0091-3057(82)90507-x.

Differential modulation of three separate K-conductances in hippocampal CA1 neurons by serotonin.

Nature. 1987;328(6125):73-7. doi: 10.1038/328073a0.

Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists.

Synapse. 1987;1(1):3-9. doi: 10.1002/syn.890010103.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

新型抗焦虑药吉哌隆、丁螺环酮和伊沙匹隆对自由进食及8-羟基二丙胺诱发进食的影响。

Effects of the novel anxiolytics gepirone, buspirone and ipsapirone on free feeding and on feeding induced by 8-OH-DPAT.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

相似文献

引用本文的文献

本文引用的文献