Ikeda Tohru, Seki Sachiko, Fujiwara Mutsunori, Matsuura Masaaki, Ozaki-Honda Yuu, Fujita Shuichi, Ikeda Hisazumi, Umeda Masahiro, Asahina Izumi
Department of Oral Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8549, Japan.
Department of Oral Pathology and Bone Metabolism, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8588, Japan.
Oncol Lett. 2017 Sep;14(3):3711-3716. doi: 10.3892/ol.2017.6575. Epub 2017 Jul 15.
A novel system auxiliary to the Union for International Cancer Control classification may allow the prognosis of patients with malignant tumors at similar stages to be predicted, as currently this is challenging. The present study generated a novel system to predict populations at low risk among patients with stage III/IV oral squamous cell carcinoma (OSCC). A total of 41 patients who were diagnosed at stages III/IV OSCC and underwent surgical tumor resection were analyzed. Band-like or follicular lymphocyte infiltration, intraepithelial micro-abscess formation and natural killer (NK) cell infiltration were histopathologically evaluated. Cox's proportional hazards regression model was used to identify prognostic factors, and a set of factors was selected from a combination of those prognostic factors to create a logic covariate model. A logic regression analysis for 41 patients with OSCC revealed that the presence of intraepithelial micro-abscesses and a lower density of NK cells were significantly associated with a favorable prognosis among patients with stage III/IV OSCC. These results suggested that the host innate immune responses, including neutrophil and NK cell infiltrations, are useful for prognostic prediction in patients with advanced malignant tumors.
国际癌症控制联盟分类辅助的一种新系统可能有助于预测处于相似阶段的恶性肿瘤患者的预后，因为目前这具有挑战性。本研究生成了一种新系统，用于预测III/IV期口腔鳞状细胞癌（OSCC）患者中的低风险人群。对总共41例诊断为III/IV期OSCC并接受手术肿瘤切除的患者进行了分析。对带状或滤泡状淋巴细胞浸润、上皮内微脓肿形成和自然杀伤（NK）细胞浸润进行了组织病理学评估。使用Cox比例风险回归模型来识别预后因素，并从这些预后因素的组合中选择一组因素来创建逻辑协变量模型。对41例OSCC患者的逻辑回归分析显示，上皮内微脓肿的存在和较低的NK细胞密度与III/IV期OSCC患者的良好预后显著相关。这些结果表明，包括中性粒细胞和NK细胞浸润在内的宿主固有免疫反应有助于晚期恶性肿瘤患者的预后预测。
