Department of Clinical Nutrition, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, No. 1665, Kongjiang Rd, Shanghai, China.
Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China.
Nutr J. 2017 Sep 19;16(1):60. doi: 10.1186/s12937-017-0280-3.
Data on the associations between circulating magnesium (Mg) levels and incidence of coronary heart diseases (CHD), hypertension, and type 2 diabetes mellitus (T2DM) are inconsistent and inconclusive. The aim of this study was to examine circulating Mg levels in relation to incidence of CHD, hypertension, and T2DM.
Prospective cohort studies published before May 2017 were searched through PubMed, EmBase, SCOPUS, and Google Scholar. A total of 11 studies that reported multivariable-adjusted associations of interest were identified. Information on the characteristics of study and participants, exposure, main outcomes, risk estimates, and cofounders was extracted and analyzed.
Of the 11 included studies, 5 reported results on CHD (38,808 individuals [4437 cases] with an average 10.5-year follow-up), 3 on hypertension (14,876 participants [3149 cases] with a 6.7-year follow-up), and 4 on T2DM (31,284 participants [2680 cases] with an 8.8-year follow-up). Comparing the highest to the lowest category of circulating Mg concentration, the pooled relative risks [RRs] (95% confidence intervals [CIs]) were 0.86 (0.74, 0.996), 0.91 (0.80, 1.02), and 0.64 (0.50, 0.81) for incidence of CHD, hypertension, and T2DM, respectively. Every 0.1 mmol/L increment in circulating Mg levels was associated with 4% (RR, 0.96; 95% CI: 0.94, 0.99) reduction in hypertension incidence. No significant linear association was found between circulating Mg levels and incidence of CHD (RR, 0.89; 95% CI: 0.77, 1.03) and T2DM (RR, 0.90; 95% CI: 0.81, 1.002). The observed associations of interest were sensitive to exclusion of individual studies.
Findings in this meta-analysis suggest that circulating Mg levels are inversely associated with incidence of CHD, hypertension, and T2DM. Additional studies are needed to provide more solid evidence and identify the optimal range of circulating Mg concentration with respect to primary prevention of CHD, hypertension, and T2DM.
关于循环镁（Mg）水平与冠心病（CHD）、高血压和 2 型糖尿病（T2DM）发病率之间的关联，现有数据并不一致，也没有明确的结论。本研究旨在探讨循环镁水平与 CHD、高血压和 T2DM 发病率之间的关系。
通过 PubMed、EmBase、SCOPUS 和 Google Scholar 检索了 2017 年 5 月前发表的前瞻性队列研究。确定了 11 项报告了感兴趣的多变量调整关联的研究。提取并分析了研究和参与者特征、暴露、主要结局、风险估计值和混杂因素的信息。
在纳入的 11 项研究中，有 5 项研究报告了 CHD 结果（38808 名个体[4437 例]，平均随访 10.5 年），3 项研究报告了高血压结果（14876 名参与者[3149 例]，平均随访 6.7 年），4 项研究报告了 T2DM 结果（31284 名参与者[2680 例]，平均随访 8.8 年）。与循环镁浓度最高组相比，最低组的汇总相对风险（RR）（95%置信区间[CI]）分别为 0.86（0.74，0.996）、0.91（0.80，1.02）和 0.64（0.50，0.81），分别用于 CHD、高血压和 T2DM 的发病率。循环镁水平每升高 0.1mmol/L，高血压的发病率就会降低 4%（RR，0.96；95%CI：0.94，0.99）。未发现循环镁水平与 CHD（RR，0.89；95%CI：0.77，1.03）和 T2DM（RR，0.90；95%CI：0.81，1.002）发病率之间存在显著的线性关联。观察到的相关性对个别研究的排除很敏感。
本荟萃分析的结果表明，循环镁水平与 CHD、高血压和 T2DM 的发病率呈负相关。需要进一步的研究提供更确凿的证据，并确定循环镁浓度的最佳范围，以预防 CHD、高血压和 T2DM。
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