Loor F, Jachez B, Montecino-Rodriguez E, Klein A S, Kuntz L, Pflumio F, Fonteneau P, Illinger D
Départment d'Immunologie, Université Louis Pasteur, Strasbourg, France.
Int J Radiat Biol Relat Stud Phys Chem Med. 1988 Jan;53(1):119-36. doi: 10.1080/09553008814550481.
The classical types of generalized autoimmune disease in man are systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Several murine strains which develop SLE and sometimes RA-like diseases are now available. They should help in the understanding of the etiopathology of SLE and RA. Basically two main therapeutic strategies which use solely irradiation have been tried; one being sublethal whole-body irradiation (WBI) and the other fractionated total lymphoid irradiation (TLI). Other protocols which combine lethal WBI and stem cell transplantation have often been attempted. It was regularly found that the bone marrow transplant (BMT) dictates the immune status of the recipient. This paper reviews the data published about NZB, NZB/W, BXSB and MRL mice in this context.
人类经典的全身性自身免疫性疾病类型是系统性红斑狼疮（SLE）和类风湿性关节炎（RA）。目前已有几种会发展为SLE且有时会出现类RA疾病的小鼠品系。它们应有助于理解SLE和RA的病因病理学。基本上已经尝试了仅使用辐射的两种主要治疗策略；一种是亚致死性全身照射（WBI），另一种是分次全淋巴照射（TLI）。人们经常尝试其他将致死性WBI与干细胞移植相结合的方案。人们经常发现骨髓移植（BMT）决定受体的免疫状态。本文在此背景下综述了已发表的关于NZB、NZB/W、BXSB和MRL小鼠的数据。
