Huang Yugang, Qi HouBao, Zhang Zhiqian, Wang Enlin, Yun Huan, Yan Hui, Su Xiaomin, Liu Yingquan, Tang Zenzen, Gao Yunhuan, Shang Wencong, Zhou Jiang, Wang Tianze, Che Yongzhe, Zhang Yuan, Yang Rongcun
State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, China.
Key Laboratory of Bioactive Materials Ministry of Education, Nankai University, Tianjin, China.
Front Immunol. 2017 Sep 4;8:1063. doi: 10.3389/fimmu.2017.01063. eCollection 2017.
Gut microbiota may not only affect composition of local immune cells but also affect systemic immune cells. However, it is not completely clear how gut microbiota modulate these immune systems. Here, we found that there exist expanded macrophage pools in γ mice. REG3γ-associated , which is homology to , could enlarge macrophage pools not only in the small intestinal lamina propria but also in the spleen and adipose tissues. STAT3-mediated signal(s) was a critical factor in the -mediated anti-inflammatory macrophages. We also offered evidence for critical cellular links among REG3γ-associated , tissue macrophages, and obesity diseases. Anti-inflammatory macrophages in the lamina propria, which are induced by REG3γ-associated , may migrate into adipose tissues and are involved in resistance against high-fat diet-mediated obesity. Thus, REG3γ-associated -induced anti-inflammatory macrophages in gut tissues may play a role in adipose tissue homeostasis.
肠道微生物群不仅可能影响局部免疫细胞的组成，还可能影响全身免疫细胞。然而，目前尚不完全清楚肠道微生物群如何调节这些免疫系统。在这里，我们发现γ小鼠中存在扩大的巨噬细胞池。与REG3γ相关的，与……同源的，不仅可以扩大小肠固有层中的巨噬细胞池，还可以扩大脾脏和脂肪组织中的巨噬细胞池。STAT3介导的信号是REG3γ相关的抗炎巨噬细胞中的关键因素。我们还提供了REG3γ相关的、组织巨噬细胞和肥胖疾病之间关键细胞联系的证据。由REG3γ相关的诱导的固有层中的抗炎巨噬细胞可能迁移到脂肪组织中，并参与抵抗高脂饮食介导的肥胖。因此，肠道组织中REG3γ相关的诱导的抗炎巨噬细胞可能在脂肪组织稳态中发挥作用。
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