Le Bourdellès B, Boularand S, Boni C, Horellou P, Dumas S, Grima B, Mallet J
Laboratoire de Neurobiologie Cellulaire et Moléculaire, CNRS, Gif sur Yvette, France.
J Neurochem. 1988 Mar;50(3):988-91. doi: 10.1111/j.1471-4159.1988.tb03009.x.
A single human gene has been described to encode multiple tyrosine hydroxylase (TH) mRNAs. The study of this variation has been extended by S1 mapping experiments and by analysis of the 5' region of the TH gene. Four different mRNAs were found to originate solely from alternative splicing of two exons. Comparison of the 5' flanking regions of human and rat genes discloses several highly conserved segments, likely to play an important role in the regulation of TH gene expression.
已有研究表明，单个人类基因可编码多种酪氨酸羟化酶（TH）mRNA。通过S1定位实验以及对TH基因5'区域的分析，对这种变异的研究得到了拓展。发现四种不同的mRNA仅源自两个外显子的可变剪接。对人类和大鼠基因5'侧翼区域的比较揭示了几个高度保守的片段，这些片段可能在TH基因表达的调控中发挥重要作用。
