Pollard B J, van der Spek A F
University Department of Anaesthesia, Manchester Royal Infirmary, UK.
J Pharm Pharmacol. 1987 Nov;39(11):896-9. doi: 10.1111/j.2042-7158.1987.tb03125.x.
The effect of trimetaphan alone and in combination with pancuronium, tubocurarine or metocurine (dimethyl tubocurarine) has been examined on the rat phrenic nerve diaphragm preparation. Trimetaphan alone produced neuromuscular blockade in an all-or-none fashion once a concentration of between 2.39 X 10(-4) and 3.00 X 10(-4) M had been exceeded. Concentrations of trimetaphan below this threshold produced a dose-dependent potentiation of all three non-depolarizing relaxants studied. This potentiation was equal for tubocurarine and metocurine, but less for pancuronium.
已在大鼠膈神经膈肌标本上研究了三甲硫吩单独使用以及与潘库溴铵、筒箭毒碱或美索曲库铵（二甲筒箭毒碱）联合使用的效果。一旦超过2.39×10⁻⁴至3.00×10⁻⁴ M的浓度，三甲硫吩单独使用会以全或无的方式产生神经肌肉阻滞。低于此阈值的三甲硫吩浓度会对所研究的所有三种非去极化松弛剂产生剂量依赖性增强作用。这种增强作用对筒箭毒碱和美索曲库铵相同，但对潘库溴铵较小。
