Influence of pH on the buccal absorption of morphine sulphate and its major metabolite, morphine-3-glucuronide.
作者信息
Al-Sayed-Omar O, Johnston A, Turner P
机构信息
Department of Clinical Pharmacology, St. Bartholomew's Hospital, London, UK.
出版信息
J Pharm Pharmacol. 1987 Nov;39(11):934-5. doi: 10.1111/j.2042-7158.1987.tb03132.x.
Abstract
Buccal absorption of morphine sulphate and morphine-3-glucuronide at various buffer pH values (4 to 10) over 5 min has been investigated in seven and four normal healthy volunteers, respectively. Increasing pH caused an increase in buccal absorption of both. The maximum mean absorption was 37% at pH 10 for morphine and 19% at pH 8 for morphine-3-glucuronide.
摘要
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