Ferferieva Vesselina, D'Elia Nicholas, Heyde Brecht, Otahal Petr, Rademakers Frank, D'hooge Jan
Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
Baker Heart and Diabetes Institute, Melbourne, Australia.
Int J Cardiovasc Imaging. 2018 Mar;34(3):385-397. doi: 10.1007/s10554-017-1246-4. Epub 2017 Sep 19.
Left ventricular remodelling (LVr) occurs post myocardial infarction (MI), predisposing people to heart failure (HF). LV mechanics and morphology are important in this process. We hence sort to characterize LV mechanics and geometry in a post-MI rodent model. Thirty-two male Sprague-Dawley rats (150-200 g) sustained MI (n = 24) or sham (Sham; n = 8) surgery. In another six sham rats invasive blood pressure measurements were performed. Ultrasound imaging was done at baseline, and 1, 3, 7, 14, 30 and 60 days following surgery, and LV mechanics and morphology assessed. LV volumes increased with time (p < 0.01), at a greater rate in the MI group than the Sham group (p < 0.01). Strain was impaired in MI rats at day 1 (13.50 ± 6.64 vs. 25.71 ± 4.94%, p < 0.01) and remained impaired at day 60 (14.07 ± 5.37 vs. 22.98 ± 5.87%, p < 0.01). Strain rate was lower at day 1 (4.11 ± 1.29 vs. 8.10 ± 2.18%/s, p < 0.01), remained lower throughout follow-up (p < 0.01), and decreased at a greater rate in MI rats (p < 0.01). Mean systolic (204 ± 43 vs. 322 ± 75 1/m, p < 0.01) and diastolic (167 ± 21 vs. 192 ± 11 1/m, p < 0.01) curvature was lower in the MI rats at day 1 post surgery and throughout follow-up (p < 0.01). Maximum principal curvature decreased throughout time (p < 0.01), while minimum principal curvature did not (p = 0.86). Wall stress increased significantly after infarction in MI rats (p < 0.01). ST-elevation myocardial infarction (STEMI) changed LV shape and contractile function. The assessment of these indices may prove useful in understanding LVr and the development of HF.
左心室重构（LVr）发生在心肌梗死（MI）后，使人易患心力衰竭（HF）。左心室力学和形态在这一过程中很重要。因此，我们试图在心肌梗死后的啮齿动物模型中对左心室力学和几何形状进行表征。32只雄性Sprague-Dawley大鼠（150 - 200克）接受了心肌梗死手术（n = 24）或假手术（假手术组；n = 8）。另外对6只假手术大鼠进行了有创血压测量。在基线以及手术后1、3、7、14、30和60天进行超声成像，并评估左心室力学和形态。左心室容积随时间增加（p < 0.01），心肌梗死组的增加速率高于假手术组（p < 0.01）。心肌梗死大鼠在第1天应变受损（13.50 ± 6.64%对25.71 ± 4.94%，p < 0.01），在第60天仍受损（14.07 ± 5.37%对22.98 ± 5.87%，p < 0.01）。应变率在第1天较低（4.11 ± 1.29%/秒对8.10 ± 2.18%/秒，p < 0.01），在整个随访过程中一直较低（p < 0.01），且在心肌梗死大鼠中下降速率更大（p < 0.01）。术后第1天及整个随访过程中，心肌梗死大鼠的平均收缩期曲率（204 ± 43对322 ± 75 1/m，p < 0.01）和舒张期曲率（167 ± 21对192 ± 11 1/m，p < 0.01）较低。最大主曲率随时间降低（p < 0.01），而最小主曲率则无变化（p = 0.86）。心肌梗死大鼠梗死后壁应力显著增加（p < 0.01）。ST段抬高型心肌梗死（STEMI）改变了左心室形状和收缩功能。对这些指标的评估可能有助于理解左心室重构和心力衰竭的发展。
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