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[高铁血红蛋白生成物质意外重度中毒:一例报告]

[Accidental severe poisoning with methemoglobinogenic substance: A case report].

作者信息

Rośniak-Bąk Kinga, Bąk Marek, Winnicka Renata, Krakowiak Anna

机构信息

Uniwersytet Medyczny w Łodzi / Medical University of Lodz, Łódź, Poland (Zakład Diagnostyki Laboratoryjnej i Biochemii Klinicznej / Department of Laboratory Diagnostics and Clinical Biochemistry).

Instytut Medycyny Pracy im. prof. J. Nofera / Nofer Institute of Occupational Medicine, Łódź, Poland (Klinika Toksykologii, Oddział Toksykologii / Toxicology Clinic, Division of Clinical Toxicology).

出版信息

Med Pr. 2017 Oct 17;68(6):795-801. doi: 10.13075/mp.5893.00572. Epub 2017 Sep 20.

Abstract

A 45-year-old male patient was admitted to the Regional Poison Center because of poisoning with dimethyloaniline contained in a toxic resin-curing dimethyl aniline-based formulation ingested inadvertently. Intoxication happened at workplace. The patient was then transferred to the Toxicology Clinic, where he stayed for 3 weeks. During the hospitalization, the primary method of treatment involved administration of methylene blue, which is the antidote of choice in such cases. During the intensive care and treatment of the patient massive intravascular hemolysis was seen. In that case treatment with blood products was required. He also showed signs of liver dysfunction due to cholestatic liver damage and jaundice. The reported case shows that severe organ damage may result from poisoning with even a small amount of the toxicant. Med Pr 2017;68(6):795-801.

摘要

一名45岁男性患者因意外摄入含二甲基苯胺的有毒树脂固化剂配方而中毒,被送往地区中毒中心。中毒发生在工作场所。随后患者被转至毒理学诊所,在那里住院3周。住院期间,主要治疗方法是使用亚甲蓝,这是此类病例的首选解毒剂。在对患者进行重症监护和治疗期间,出现了大量血管内溶血。在这种情况下,需要使用血液制品进行治疗。他还因胆汁淤积性肝损伤和黄疸出现肝功能障碍的迹象。报告的病例表明,即使少量毒物中毒也可能导致严重器官损伤。《医学实践》2017年;68(6):795 - 801。

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