Simkó Csaba
Erzsébet Hospice Otthon, Borsod-Abaúj-Zemplén Megyei Központi Kórház és Egyetemi Oktatókórház, Miskolc, Hungary.
Magy Onkol. 2017 Sep 20;61(3):247-257. Epub 2017 Jul 22.
Nausea and vomiting are frequent and fearful issues both of cancer itself and its treatment, resulting in reduced quality of life, hospitalization and unnecessary medical investigations. Unconventionally, the author discusses the treatment-related and non-treatment-related complaints together, so as to give an integrated approach to this problem. Different types of nausea/vomiting and important causes are explained by discussion of the pathophysiology and clinical symptoms. Different classes of antiemetics are detailed, emphasizing the evolving role of olanzapine in the treatment of both the acute and delayed type of chemotherapy-induced nausea/vomiting. It was no aim of this review to detail all aspects of MASCC and ESMO antiemetic guideline issued in 2016, but the main topics are presented together with other antiemetic strategies.
恶心和呕吐是癌症本身及其治疗过程中常见且令人担忧的问题,会导致生活质量下降、住院以及不必要的医学检查。不同寻常的是,作者将与治疗相关和与治疗无关的主诉放在一起讨论,以便对这一问题给出综合的处理方法。通过对病理生理学和临床症状的讨论,解释了不同类型的恶心/呕吐及其重要病因。详细介绍了不同类别的止吐药,强调了奥氮平在治疗急性和迟发性化疗引起的恶心/呕吐中不断演变的作用。本综述的目的不是详述2016年发布的MASCC和ESMO止吐指南的所有方面,而是将主要主题与其他止吐策略一起呈现。