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[实体瘤化疗所致发热性中性粒细胞减少症的治疗]

[Treatment of chemotherapy-induced febrile neutropenia in solid tumors].

作者信息

Gálffy Gabriella

机构信息

Pulmonológiai Klinika, Semmelweis Egyetem, Budapest, Hungary.

出版信息

Magy Onkol. 2017 Sep 20;61(3):261-266. Epub 2017 Aug 28.

Abstract

One of the most dangerous complications of bone marrow suppression due to chemotherapy is febrile neutropenia. The treatment of the affected patients is a multidisciplinary task. In addition to chemotherapy, adequate G-CSF therapy as a primary and secondary prophylaxis can be used to prevent a large part of febrile neutropenic events. Before each chemotherapy cycle, the risk of febrile neutropenia should be evaluated, taking into account the chemotherapeutic combination and patient-specific parameters. Appropriate antibiotic and G-CSF therapy initiated in the course of febrile neutropenia is essential for the success of the therapy. The oncologists can reach treatment success in the patient's therapy if he or she provides the patient the adequate supportive medications at the appropriate time.

摘要

化疗引起的骨髓抑制最危险的并发症之一是发热性中性粒细胞减少。对受影响患者的治疗是一项多学科任务。除化疗外,可使用适当的粒细胞集落刺激因子(G-CSF)疗法作为一级和二级预防措施,以预防大部分发热性中性粒细胞减少事件。在每个化疗周期前,应评估发热性中性粒细胞减少的风险,同时考虑化疗方案和患者的个体参数。在发热性中性粒细胞减少过程中启动适当的抗生素和G-CSF治疗对于治疗成功至关重要。如果肿瘤学家在适当的时候为患者提供足够的支持性药物,那么在患者的治疗中就能取得治疗成功。

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