Urs Aadithya B, Kumar Priya, Augustine Jeyaseelan, Malhotra Rewa
Department of Oral Pathology and Microbiology, Maulana Azad Institute of Dental Sciences, New Delhi, India.
J Oral Maxillofac Pathol. 2017 May-Aug;21(2):239-243. doi: 10.4103/jomfp.JOMFP_167_16.
Glandular odontogenic cyst (GOC) is a clinically rare and histopathologically unusual type of developmental odontogenic cyst with unpredictable and potentially aggressive behaviour.
Archival data of cases histopathologically identified as GOC were analyzed from the Department of Oral Pathology over the past six years. The clinical, radiographic, histopathological features and treatment were evaluated. Special stains such as periodic acid Schiff, mucicarmine along with immunohistochemical staining for cytokeratin 19 were employed to confirm the histopathological diagnosis.
The study indicated a strong female predilection with slightly more number of cases found in maxilla than mandible. Most cases showed a well defined multilocular radiolucency. The microscopic features which aid in its differentiation from its mimickers such as central mucoepidermoid carcinoma, lateral periodontal cyst, dentigerous cyst and botryoid odontogenic cyst which were observed included presence of variable thickness of the lining epithelium, epithelial plaques and whorls, hobnail cells, ciliated cells, clear cells and goblet cells.
The present case series aims to throw light on the clinical, radiographic and microscopic features of GOC, which may aid in its definitive diagnosis in problematic cases.
腺牙源性囊肿（GOC）是一种临床上罕见且组织病理学上不寻常的发育性牙源性囊肿，具有不可预测的潜在侵袭性行为。
分析过去六年口腔病理科组织病理学确诊为GOC的病例档案资料。对临床、影像学、组织病理学特征及治疗情况进行评估。采用过碘酸希夫染色、黏液卡红染色以及细胞角蛋白19免疫组化染色等特殊染色方法来确诊组织病理学诊断。
研究表明女性明显更易患病，上颌骨病例数略多于下颌骨。多数病例表现为边界清晰的多房性透射区。观察到有助于将其与诸如中央黏液表皮样癌、侧方牙周囊肿、含牙囊肿及葡萄状牙源性囊肿等相似病变相鉴别的微观特征，包括衬里上皮厚度不一、上皮斑和漩涡、鞋钉样细胞、纤毛细胞、透明细胞及杯状细胞。
本病例系列旨在阐明GOC的临床、影像学及微观特征，这可能有助于在疑难病例中对其进行明确诊断。
