Sivam S P, Breese G R, Napier T C, Mueller R A, Hong J S
Neuropharmacology Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.
NIDA Res Monogr. 1986;75:389-92.
Dopaminergic denervation by 6-hydroxydopamine (6-OHDA) increased proenkephalin-A gene expression in the striatum as evidenced by increases in the levels of Met5-enkephalin (ME), precursor and preproenkephalin mRNA (PE-mRNA). This and other lines of evidence support the hypothesis that nigrostriatal dopamine input is inhibitory to striatal enkephalin neurons and that the removal of this inhibitory influence leads to an acceleration of ME biosynthesis. These findings suggest that the enkephalin system may be associated with the progression of adaptive changes subsequent to dopaminergic dysfunction in basal ganglia.
6-羟基多巴胺（6-OHDA）所致的多巴胺能去神经支配增加了纹状体中前脑啡肽原-A基因的表达，这可通过甲硫氨酸脑啡肽（ME）、前体及前脑啡肽原mRNA（PE-mRNA）水平的升高得以证明。这一发现及其他证据支持了以下假说：黑质纹状体多巴胺输入对纹状体脑啡肽能神经元具有抑制作用，而这种抑制作用的消除会导致ME生物合成加速。这些结果表明，脑啡肽系统可能与基底神经节多巴胺能功能障碍后适应性变化的进展相关。
