体外培养的大鼠杏仁核切片中免疫反应性甲硫氨酸脑啡肽的释放。
Release of i-r metenkephalin from rat amygdala slices in vitro.
作者信息
Livingston A, Morris B
机构信息
Dept. of Pharmacology, Medical School, Bristol, U.K.
出版信息
NIDA Res Monogr. 1986;75:418-21.
Release of immuno-reactive metenkephalin has been demonstrated from slices of rat amygdala in vitro. This release was calcium dependent and the amount released was related to the concentration of potassium ions in the releasing stimulus. The effect of drugs such as clonidine, an alpha 2 adrenoceptor agonist, and idazoxan, an antagonist, on this release was measured. Neither drug had a significant effect on the amount of ir-metenkephalin released. Thus although release of noradrenaline can be affected by opioids it seems that release of endogenous opioids is not affected by drugs which interact with noradrenaline.
免疫反应性甲硫脑啡肽已在体外大鼠杏仁核切片中得到释放证实。这种释放依赖于钙，且释放量与释放刺激中钾离子的浓度有关。测量了可乐定（一种α₂肾上腺素能受体激动剂）和咪唑克生（一种拮抗剂）等药物对这种释放的影响。两种药物对免疫反应性甲硫脑啡肽的释放量均无显著影响。因此，尽管去甲肾上腺素的释放可受阿片类药物影响，但内源性阿片类药物的释放似乎不受与去甲肾上腺素相互作用的药物影响。
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