Tejwani G A, Richard C W
Department of Pharmacology, College of Medicine, Ohio State University, Columbus 43210.
NIDA Res Monogr. 1986;75:497-500.
The hyperphagia and obesity induced by ventromedial hypothalamic (VMH) electrolytic lesions in female rats were associated with a 70-94% decrease in the level of beta-endorphin (beta-E) in the hypothalamus and other regions of brain, but not in the pituitary. Dynorphin (Dyn) and methionine-enkephalin (ME) levels were also decreased. Rats with VMH lesions were less sensitive to the inhibitory effect of naloxone on their food-intake. Mice injected with gold thioglucose (GTG) also showed a decrease in the hypothalamic content of beta-E and Dyn and exhibited 30% less analgesia compared to control mice after cold swim stress.
腹内侧下丘脑（VMH）电解损伤诱导的雌性大鼠食欲亢进和肥胖与下丘脑及脑其他区域而非垂体中β-内啡肽（β-E）水平降低70%-94%有关。强啡肽（Dyn）和甲硫氨酸脑啡肽（ME）水平也降低。VMH损伤的大鼠对纳洛酮抑制其食物摄入的作用不太敏感。注射硫代葡萄糖金（GTG）的小鼠下丘脑β-E和Dyn含量也降低，且在冷泳应激后与对照小鼠相比镇痛作用降低30%。
