一种产生活性氧物种、抑制环氧化酶-2、具有癌症干细胞潜能的四核铜（II）簇。
A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(ii) cluster.
机构信息
Department of Chemistry, King's College London, London, SE1 1DB, UK.
出版信息
Dalton Trans. 2017 Oct 14;46(38):12785-12789. doi: 10.1039/c7dt02789c. Epub 2017 Sep 21.
PMID:28932846
Abstract
Tetranuclear copper(ii) complexes containing multiple diclofenac and Schiff base moieties, 1-4, are shown to kill bulk cancer cells and cancer stem cells (CSCs) with low micromolar potency. The most effective complex, 1, elicits its cytotoxic effect by elevating the intracellular reactive oxygen species (ROS) levels and inhibiting cyclooxygenase-2 (COX-2) expression.
摘要
含有多个双氯芬酸和席夫碱部分的四核铜（II）配合物 1-4 被证明具有低微摩尔效力，可杀死大量癌细胞和癌症干细胞（CSCs）。最有效的配合物 1 通过提高细胞内活性氧（ROS）水平和抑制环氧化酶-2（COX-2）表达来发挥其细胞毒性作用。
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