Faculty of Pharmaceutical Sciences, School of Health Sciences, University of Iceland , Hofsvallagata 53, IS-107 Reykjavik, Iceland.
Biomacromolecules. 2017 Nov 13;18(11):3846-3868. doi: 10.1021/acs.biomac.7b01058. Epub 2017 Oct 3.
This review gives an updated overview of the current state-of-the-art for antimicrobial chitosan and chitosan derivatives and the effects of structural modifications on activity and toxicity. The various synthetic routes introduced for chemical modification of chitosan are discussed, and the most common functional groups are highlighted. Different analytical techniques used for structural characterization of the synthesized chitosan derivatives are discussed and critically evaluated. For the purpose of this review, the antimicrobial chitosan derivatives have been classified on the basis of the type of functional group conjugated to the polymer backbone. In each case, the influence of the degree of substitution on the biological properties has been examined. Finally, we have summarized the collective information and suggested future directions for further research to improve our understanding of the bioactivity and to develop more useful chitosan conjugates.
这篇综述更新了抗菌壳聚糖和壳聚糖衍生物的最新研究进展，以及结构修饰对其活性和毒性的影响。讨论了壳聚糖化学修饰的各种合成途径，并强调了最常见的功能基团。讨论并批判性地评估了用于合成壳聚糖衍生物结构表征的不同分析技术。出于本综述的目的，根据与聚合物主链结合的官能团类型，对抗菌壳聚糖衍生物进行了分类。在每种情况下，都研究了取代度对生物性质的影响。最后，我们总结了综合信息，并提出了未来的研究方向，以提高我们对生物活性的理解，并开发更有用的壳聚糖缀合物。
