鞘内注射后生长抑素在大鼠脊髓中的抗伤害感受和“神经毒性”作用
Antinociceptive and 'neurotoxic' actions of somatostatin in rat spinal cord after intrathecal administration.
作者信息
Mollenholt Peter, Post Claes, Rawal Narinder, Freedman Jacob, Hökfelt Tomas, Paulsson Ivar
机构信息
Department of Anaesthesia and Intensive Care, Örebro Medical Centre Hospital, S-701 85 ÖrebroSweden Astro Research and Development Laboratories and Astra Toxicological Laboratories, S-I5I 85 SödertäljeSweden Department of Histology, Karolinska Institute, S-104 01 StockholmSweden.
出版信息
Pain. 1988 Jan;32(1):95-105. doi: 10.1016/0304-3959(88)90028-0.
In the present investigation, the antinociceptive effect of somatostatin (SST) was assessed after intrathecal injection in rats. It was found that the peptide caused antinociception, hind limb paralysis and neuronal damage of the spinal cord in a dose-dependent manner. The threshold dose for antinociception was lower (approximately 10 micrograms) than that (approximately 30 micrograms) giving rise to chronic motor impairment associated with necrotic changes and loss of an immunohistochemical marker for motoneurons in the spinal cord. It is concluded that the 'neurotoxic' potential of SST should be considered in further clinical trials.
在本研究中，对大鼠鞘内注射生长抑素（SST）后其镇痛作用进行了评估。发现该肽以剂量依赖性方式引起镇痛、后肢麻痹和脊髓神经元损伤。镇痛的阈剂量（约10微克）低于引起与脊髓运动神经元坏死性改变和免疫组化标记物丧失相关的慢性运动障碍的剂量（约30微克）。得出结论，在进一步的临床试验中应考虑SST的“神经毒性”潜力。
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