Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50383 Wroclaw, Poland.
Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via A. Moro 2, 53100 Siena, Italy.
Curr Med Chem. 2019;26(4):624-647. doi: 10.2174/0929867324666170920125943.
Silver is a non-essential element with promising antimicrobial and anticancer properties. This work is a detailed summary of the newest findings on the bioinorganic chemistry of silver, with a special focus on the applications of Ag+ complexes and nanoparticles. The coordination chemistry of silver is given a reasonable amount of attention, summarizing the most common silver binding sites and giving examples of such binding motifs in biologically important proteins. Possible applications of this metal and its complexes in medicine, particularly as antibacterial and antifungal agents and in cancer therapy, are discussed in detail. The most recent data on silver nanoparticles are also summarized.
银是一种非必需元素，具有有前景的抗菌和抗癌特性。这项工作详细总结了银的生物无机化学的最新发现，特别关注 Ag+ 配合物和纳米粒子的应用。银的配位化学得到了相当的关注，总结了最常见的银结合位点，并举例说明了在重要生物蛋白中的这种结合模式。讨论了该金属及其配合物在医学中的可能应用，特别是作为抗菌和抗真菌剂以及在癌症治疗中的应用。还总结了最近关于银纳米粒子的数据。
