• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

STAT3-regulated RhoA drives reactive astrocyte dynamics.

作者信息

Renault-Mihara Francois, Okano Hideyuki

机构信息

a Department of Physiology , Keio University School of Medicine , 35 Shinanomachi, Shinjuku-ku , Tokyo , Japan.

出版信息

Cell Cycle. 2017;16(21):1995-1996. doi: 10.1080/15384101.2017.1377032. Epub 2017 Sep 29.

DOI:10.1080/15384101.2017.1377032
PMID:28933592
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5731407/
Abstract
摘要

相似文献

1
STAT3-regulated RhoA drives reactive astrocyte dynamics.信号转导和转录激活因子3（STAT3）调控的RhoA驱动反应性星形胶质细胞的动态变化。
Cell Cycle. 2017;16(21):1995-1996. doi: 10.1080/15384101.2017.1377032. Epub 2017 Sep 29.
2
Regulation of RhoA by STAT3 coordinates glial scar formation.STAT3对RhoA的调控协调了胶质瘢痕形成。
J Cell Biol. 2017 Aug 7;216(8):2533-2550. doi: 10.1083/jcb.201610102. Epub 2017 Jun 22.
3
Astrocytic CCAAT/Enhancer-Binding Protein Delta Contributes to Glial Scar Formation and Impairs Functional Recovery After Spinal Cord Injury.星形胶质细胞CCAAT/增强子结合蛋白δ促进胶质瘢痕形成并损害脊髓损伤后的功能恢复。
Mol Neurobiol. 2016 Nov;53(9):5912-5927. doi: 10.1007/s12035-015-9486-6. Epub 2015 Oct 28.
4
STAT3: Down the R(h)oAd.信号转导及转录激活蛋白3：进展之路
Cytokine. 2018 Feb;102:149-150. doi: 10.1016/j.cyto.2017.08.003. Epub 2017 Aug 10.
5
[Studies on the effects of astrocyte during glial scar formation by recombinant antisense GFAP retrovirus].[重组反义胶质纤维酸性蛋白逆转录病毒对星形胶质细胞在胶质瘢痕形成过程中作用的研究]
Sheng Li Ke Xue Jin Zhan. 1999 Apr;30(2):133-6.
6
Signaling molecules regulating phenotypic conversions of astrocytes and glial scar formation in damaged nerve tissues.调节受损神经组织中星形胶质细胞表型转化和胶质瘢痕形成的信号分子。
Neurochem Int. 2014 Dec;78:35-42. doi: 10.1016/j.neuint.2014.08.005. Epub 2014 Aug 30.
7
The characterization of astrocyte cell lines that display properties of glial scar tissue.对表现出胶质瘢痕组织特性的星形胶质细胞系的表征。
Dev Biol. 1993 Sep;159(1):87-104. doi: 10.1006/dbio.1993.1223.
8
The JAK/STAT3 pathway is a common inducer of astrocyte reactivity in Alzheimer's and Huntington's diseases.JAK/STAT3信号通路是阿尔茨海默病和亨廷顿舞蹈病中星形胶质细胞反应性的常见诱导因素。
J Neurosci. 2015 Feb 11;35(6):2817-29. doi: 10.1523/JNEUROSCI.3516-14.2015.
9
Effect of CLIP3 Upregulation on Astrocyte Proliferation and Subsequent Glial Scar Formation in the Rat Spinal Cord via STAT3 Pathway After Injury.CLIP3 上调通过 STAT3 通路对大鼠脊髓损伤后星形胶质细胞增殖和随后的胶质瘢痕形成的影响。
J Mol Neurosci. 2018 Jan;64(1):117-128. doi: 10.1007/s12031-017-0998-6. Epub 2017 Dec 7.
10
The complex STATes of astrocyte reactivity: How are they controlled by the JAK-STAT3 pathway?星形胶质细胞反应性的复杂状态：它们如何由JAK-STAT3信号通路控制？
Neuroscience. 2016 Aug 25;330:205-18. doi: 10.1016/j.neuroscience.2016.05.043. Epub 2016 May 27.

引用本文的文献

1
Single-Nucleus Profiling Identifies Accelerated Oligodendrocyte Precursor Cell Senescence in a Mouse Model of Down Syndrome.单细胞基因图谱分析鉴定出唐氏综合征小鼠模型中少突胶质前体细胞的加速衰老。
eNeuro. 2023 Aug 23;10(8). doi: 10.1523/ENEURO.0147-23.2023. Print 2023 Aug.
2
Macrophages play a leading role in determining the direction of astrocytic migration in spinal cord injury via ADP-P2Y1R axis.巨噬细胞通过 ADP-P2Y1R 轴在脊髓损伤中对星形胶质细胞迁移的方向起主导作用。
Sci Rep. 2023 Jul 10;13(1):11177. doi: 10.1038/s41598-023-38301-8.
3
Macrophages play a leading role in determining the direction of astrocytic migration in spinal cord injury via ADP-P2Y1R axis.巨噬细胞通过ADP-P2Y1R轴在脊髓损伤中星形胶质细胞迁移方向的决定中起主导作用。
Res Sq. 2023 Jan 9:rs.3.rs-2427082. doi: 10.21203/rs.3.rs-2427082/v1.
4
Advantages of Rho-associated kinases and their inhibitor fasudil for the treatment of neurodegenerative diseases.Rho相关激酶及其抑制剂法舒地尔在治疗神经退行性疾病方面的优势。
Neural Regen Res. 2022 Dec;17(12):2623-2631. doi: 10.4103/1673-5374.335827.
5
Vav3-Deficient Astrocytes Enhance the Dendritic Development of Hippocampal Neurons in an Indirect Co-culture System.在间接共培养系统中，Vav3基因缺陷型星形胶质细胞促进海马神经元的树突发育。
Front Cell Neurosci. 2022 Feb 14;15:817277. doi: 10.3389/fncel.2021.817277. eCollection 2021.
6
miR-21a-5p Promotes Inflammation following Traumatic Spinal Cord Injury through Upregulation of Neurotoxic Reactive Astrocyte (A1) Polarization by Inhibiting the CNTF/STAT3/Nkrf Pathway.微小RNA-21a-5p通过抑制CNTF/STAT3/Nkrf信号通路上调神经毒性反应性星形胶质细胞（A1）极化，从而促进创伤性脊髓损伤后的炎症反应。
Int J Biol Sci. 2021 Jul 5;17(11):2795-2810. doi: 10.7150/ijbs.60509. eCollection 2021.
7
Systematic analysis of purified astrocytes after SCI unveils Zeb2os function during astrogliosis.对 SCI 后纯化的星形胶质细胞进行系统分析揭示了 Zeb2os 在星形胶质细胞增生中的作用。
Cell Rep. 2021 Feb 2;34(5):108721. doi: 10.1016/j.celrep.2021.108721.
8
The role of astrocytes in oxidative stress of central nervous system: A mixed blessing.星形胶质细胞在中枢神经系统氧化应激中的作用：利弊参半。
Cell Prolif. 2020 Mar;53(3):e12781. doi: 10.1111/cpr.12781. Epub 2020 Feb 8.
9
Targeted inhibition of STAT3 as a potential treatment strategy for atherosclerosis.靶向抑制 STAT3 作为动脉粥样硬化潜在的治疗策略。
Theranostics. 2019 Aug 14;9(22):6424-6442. doi: 10.7150/thno.35528. eCollection 2019.

本文引用的文献

1
Regulation of RhoA by STAT3 coordinates glial scar formation.STAT3对RhoA的调控协调了胶质瘢痕形成。
J Cell Biol. 2017 Aug 7;216(8):2533-2550. doi: 10.1083/jcb.201610102. Epub 2017 Jun 22.
2
Control of astrocyte morphology by Rho GTPases.Rho GTPases 对星形胶质细胞形态的调控。
Brain Res Bull. 2018 Jan;136:44-53. doi: 10.1016/j.brainresbull.2017.05.003. Epub 2017 May 11.
3
Glial scar borders are formed by newly proliferated, elongated astrocytes that interact to corral inflammatory and fibrotic cells via STAT3-dependent mechanisms after spinal cord injury.胶质瘢痕边界由新增殖的、伸长的星形胶质细胞形成，这些细胞通过 STAT3 依赖的机制相互作用，在脊髓损伤后隔离炎症和纤维细胞。
J Neurosci. 2013 Jul 31;33(31):12870-86. doi: 10.1523/JNEUROSCI.2121-13.2013.
4
The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells.抑癌基因 PTEN 可通过外泌体被输出，并在靶细胞中发挥磷酸酶活性。
Sci Signal. 2012 Sep 25;5(243):ra70. doi: 10.1126/scisignal.2003084.
5
Stat3 promotes directional cell migration by regulating Rac1 activity via its activator betaPIX.Stat3 通过其激活剂 betaPIX 调节 Rac1 活性促进细胞定向迁移。
J Cell Sci. 2009 Nov 15;122(Pt 22):4150-9. doi: 10.1242/jcs.057109. Epub 2009 Oct 27.
6
Matrix metalloproteinase-2 facilitates wound healing events that promote functional recovery after spinal cord injury.基质金属蛋白酶-2促进脊髓损伤后促进功能恢复的伤口愈合过程。
J Neurosci. 2006 Sep 27;26(39):9841-50. doi: 10.1523/JNEUROSCI.1993-06.2006.
7
Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury.Stat3或Socs3的条件性消融揭示了脊髓损伤后反应性星形胶质细胞的双重作用。
Nat Med. 2006 Jul;12(7):829-34. doi: 10.1038/nm1425. Epub 2006 Jun 18.