1 Faculty of Medicine and Health Sciences, University of Nottingham, UK.
2 Sobell Department of Motor Neuroscience, UCL Institute of Neurology, Queen Square; National Hospital for Neurology and Neurosurgery, Queen Square; UCLP Centre for Neurorehabilitation, Queen Square, UK.
Clin Rehabil. 2017 Oct;31(10):1406-1415. doi: 10.1177/0269215517695857. Epub 2017 Mar 1.
To identify factors associated with post-stroke fatigue in a sample of stroke survivors without depression.
Cross-sectional cohort study.
Recruitment was from four stroke units in the UK.
Participants were assessed within four to six weeks of first stroke; those with high levels of depressive symptoms (score ⩾7 Brief Assessment Schedule Depression Cards) were excluded.
Participants were assessed after stroke on the Fatigue Severity Scale of the Fatigue Assessment Inventory, the Rivermead Mobility Index, Nottingham Extended Activities of Daily Living scale, Beck Anxiety Index, Sleep Hygiene Index, 6m walk test, and measures of cognitive ability.
Of the 371 participants recruited, 103 were excluded and 268 were assessed. Of the latter, the mean age was 67.7 years (SD 13.5) and 168 (63%) were men. The National Institutes of Health Stroke Scale mean score was 4.96 (SD 4.12). Post-stroke fatigue was reported by 115 (43%) of participants, with 71 (62%) reporting this to be a new symptom since their stroke. Multivariate analysis using the Fatigue Severity Scale as the outcome variable found pre-stroke fatigue, having a spouse/partner, lower Rivermead Mobility Index score, and higher scores on both the Brief Assessment Schedule Depression Cards and Beck Anxiety Index were independently associated with post-stroke fatigue, accounting for approximately 47% of the variance in Fatigue Severity Scale scores.
Pre-stroke fatigue, lower mood, and poorer mobility were associated with post-stroke fatigue.
在无抑郁的卒中幸存者样本中确定与卒中后疲劳相关的因素。
横断面队列研究。
在英国的四个卒中病房招募。
参与者在首次卒中后 4 至 6 周内进行评估；排除有高抑郁症状（Brief Assessment Schedule Depression Cards 评分 ⩾7）的患者。
卒中后，参与者使用疲劳评估量表的疲劳严重程度量表、Rivermead 移动指数、诺丁汉扩展日常生活活动量表、贝克焦虑量表、睡眠卫生指数、6m 步行测试和认知能力测量进行评估。
在招募的 371 名参与者中，103 名被排除，268 名接受了评估。在后者中，平均年龄为 67.7 岁（SD 13.5），168 名（63%）为男性。国立卫生研究院卒中量表的平均评分为 4.96（SD 4.12）。115 名（43%）参与者报告有卒中后疲劳，其中 71 名（62%）报告这是卒中后的新症状。使用疲劳严重程度量表作为因变量的多变量分析发现，卒中前疲劳、有配偶/伴侣、较低的 Rivermead 移动指数评分、Brief Assessment Schedule Depression Cards 和贝克焦虑量表评分较高与卒中后疲劳独立相关，可解释疲劳严重程度量表评分约 47%的差异。
卒中前疲劳、情绪低落和活动能力较差与卒中后疲劳有关。
