Rosendahl M, Simonsen M K, Kjer J J
a Department of Gynecology , Copenhagen University Hospital-Rigshospitalet , Copenhagen , Denmark.
b Diakonissestiftelsen & Research Unit, Dietary Studies at the Parker Institute , Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital , Copenhagen , Denmark.
Climacteric. 2017 Dec;20(6):540-544. doi: 10.1080/13697137.2017.1369512. Epub 2017 Sep 21.
To determine the age of menopause after premenopausal unilateral oophorectomy (UO) and to establish whether UO at a young age leads to menopause at a younger age than if UO occurs at an older age.
A cohort of 28 731 women, of whom 17 781 (62%) were menopausal, was investigated. Information on menopause was obtained from self-reported questionnaires. Surgical data were obtained from the National Patient Register to avoid recollection bias. Age of menopause after UO/not UO was determined using Kaplan-Meier curves. Cox regression was used to identify factors of importance for early menopause.
UO was performed in 1148 women. Women with UO after the age of 45 years, premenopausal hysterectomy, bilateral oophorectomy and cancer were excluded, leaving 236 in the analysis. Menopause occurred 1.8 years earlier after UO compared to women with two intact ovaries (mean 49.5 vs. 51.3 years), and younger age at UO was significantly linearly correlated to younger age at menopause. UO (hazard ratio 1.23) and smoking (hazard ratio 1.12) significantly decreased the age of menopause.
Premenopausal unilateral oophorectomy significantly reduces the age of menopause by 1.8 years. Younger age at UO leads to significantly younger age at menopause.
确定绝经前单侧卵巢切除术（UO）后的绝经年龄，并确定年轻时进行UO是否比年长时进行UO导致绝经年龄更小。
对28731名女性进行队列研究，其中17781名（62%）已绝经。绝经信息通过自我报告问卷获得。手术数据从国家患者登记处获取，以避免回忆偏差。使用Kaplan-Meier曲线确定UO/未进行UO后的绝经年龄。采用Cox回归确定早绝经的重要影响因素。
1148名女性接受了UO。排除45岁后进行UO、绝经前子宫切除术、双侧卵巢切除术和癌症患者，分析中剩余236名。与双侧卵巢完整的女性相比，UO后绝经提前1.8年（平均49.5岁对51.3岁），且UO时年龄越小与绝经时年龄越小显著线性相关。UO（风险比1.23）和吸烟（风险比1.12）显著降低绝经年龄。
绝经前单侧卵巢切除术可使绝经年龄显著提前1.8年。UO时年龄越小，绝经时年龄越小。
