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一家儿童医院十二年的卵巢组织冷冻保存：跟踪项目及患者指标，同时适应不断增长的需求。

A dozen years of ovarian tissue cryopreservation at a pediatric hospital: tracking program and patient metrics while adapting to increasing needs.

作者信息

McElhinney Kathryn L, Kennedy Tara, Rowell Erin E, Laronda Monica M

机构信息

Department of Surgery, Division of Pediatric Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Fertility & Hormone Preservation & Restoration Program, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.

出版信息

F S Rep. 2024 Feb 16;5(2):197-204. doi: 10.1016/j.xfre.2024.02.009. eCollection 2024 Jun.

DOI:10.1016/j.xfre.2024.02.009
PMID:38983744
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11228781/
Abstract

OBJECTIVE

To review the program and patient metrics for ovarian tissue cryopreservation (OTC) within a comprehensive pediatric fertility preservation program in its first 12 years of development.

DESIGN

Retrospective review.

SETTING

A tertiary children's hospital in a large urban center between March 2011 and February 2023.

PATIENTS

Pediatric patients who underwent OTC.

INTERVENTIONS

Unilateral oophorectomy for OTC.

MAIN OUTCOME MEASURES

Patient demographics and clinical course information were collected for analysis.

RESULTS

A total of 184 patients underwent OTC in the first 12 years. One hundred fifteen patients were prepubertal at the time of OTC, and 69 were postpubertal. In total, 128 patients (69.6%) received part of their planned therapy before OTC. Starting in 2018, 104 participants (92.0%) donated tissue to research, 99 participants (87.6%) donated blood, and 102 (90.2%) donated media to research. There was a decrease in the median age of patients who underwent OTC from 16.4-6.6 years and an overall increase in the proportion of patients per year that were prepubertal. Forty-eight (26.0%) patients who underwent OTC were outside referrals and traveled from as far as Seattle, Washington.

CONCLUSION

During the first 12 years of this program, oncofertility research increased, annual tissue cryopreservation cases increased, and the median age of those who underwent OTC decreased. The program was adapted to build a stand-alone gonadal tissue processing suite and specialized in prepubertal ovarian tissue processing. The program will continue to adapt to patient needs in the upcoming decades because restoration technologies advance through research supported by this and collaborating programs.

摘要

目的

回顾一个综合性儿科生育力保存项目在其发展的前12年中卵巢组织冷冻保存（OTC）的项目情况和患者指标。

设计

回顾性研究。

地点

2011年3月至2023年2月期间，位于一个大型城市中心的一家三级儿童医院。

患者

接受OTC的儿科患者。

干预措施

为进行OTC而实施单侧卵巢切除术。

主要观察指标

收集患者人口统计学和临床病程信息进行分析。

结果

在最初的12年里，共有184例患者接受了OTC。其中115例患者在进行OTC时处于青春期前，69例处于青春期后。总计128例患者（69.6%）在OTC之前接受了部分计划治疗。从2018年开始，104名参与者（92.0%）捐赠组织用于研究，99名参与者（87.6%）捐赠血液，102名（90.2%）捐赠培养基用于研究。接受OTC的患者中位年龄从16.4岁降至6.6岁，青春期前患者每年的比例总体上升。48例（26.0%）接受OTC的患者是外部转诊而来，最远来自华盛顿州的西雅图。

结论

在该项目的前12年中，肿瘤生育力研究增加，每年的组织冷冻保存病例增加，接受OTC的患者中位年龄下降。该项目进行了调整，建立了一个独立的性腺组织处理套件，并专门从事青春期前卵巢组织处理。由于恢复技术通过本项目及合作项目支持的研究取得进展，该项目在未来几十年将继续根据患者需求进行调整。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b2/11228781/6fdb2ef84236/figs2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b2/11228781/acbbc93d0af7/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b2/11228781/e55b3df74e36/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b2/11228781/313e1c3c0b9f/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b2/11228781/e171d00309d6/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b2/11228781/6fdb2ef84236/figs2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b2/11228781/acbbc93d0af7/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b2/11228781/e55b3df74e36/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b2/11228781/313e1c3c0b9f/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b2/11228781/e171d00309d6/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13b2/11228781/6fdb2ef84236/figs2.jpg

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