Dinan T G
Department of Psychological Medicine, St. Bartholomew's Hospital, London.
Psychol Med. 1987 Nov;17(4):875-81. doi: 10.1017/s0033291700000672.
Platelet-rich plasma from healthy controls was pre-treated with neuroleptics of the phenothiazine, butyrophenone or benzamide variety before aggregation with one of the following agonist agents: ADP, adrenaline, 5-HT, collagen, platelet activating factor or ristocetin. All compounds effective as antipsychotics, except sulpiride, depressed aggregation. Unmedicated schizophrenics showed aggregation responses indistinguishable from healthy controls. However, within days of treatment with either trifluoroperazine or haloperidol responses became abnormal in acutely psychotic patients. Increased responses to 5-HT and depressed responses to platelet activating factor were detected. After 4 weeks of treatment responses tended to return to normal. Aggregation responses were normal in those patients on long-term depot neuroleptics.
来自健康对照者的富血小板血浆在与以下激动剂之一聚集之前，先用吩噻嗪类、丁酰苯类或苯甲酰胺类抗精神病药物进行预处理：ADP、肾上腺素、5-羟色胺、胶原、血小板活化因子或瑞斯托霉素。除舒必利外，所有有效的抗精神病化合物均抑制聚集。未用药的精神分裂症患者的聚集反应与健康对照者无明显差异。然而，在用三氟拉嗪或氟哌啶醇治疗数天内，急性精神病患者的反应变得异常。检测到对5-羟色胺的反应增加，对血小板活化因子的反应降低。治疗4周后，反应趋于恢复正常。长期使用长效抗精神病药物的患者的聚集反应正常。
