Barrios V, Fernandez Iriarte M C, Morcillo E, Prieto J C, Arilla E
Departamento de Bioquímica, Universidad de Alcalá de Henares, Madrid, Spain.
Regul Pept. 1987 Nov;19(3-4):161-8. doi: 10.1016/0167-0115(87)90273-4.
In guinea pigs sensitized with 1 microgram ovalbumin together with 100 mg Al(OH)3, somatostatin levels were selectively increased up to two and 3 times in tissue extracts from trachea and bronchi, respectively, but not in lung as compared to controls. The increase of somatostatin levels observed in trachea and bronchi after sensitization was associated with a decrease in the binding capacity of both high- and low-affinity binding sites (without changes in the affinity values) in the corresponding cytosolic fractions. These results suggests that an increase in airways somatostatin content may be involved in the pathogenesis of anaphylactic bronchoconstriction.
在用1微克卵清蛋白与100毫克氢氧化铝致敏的豚鼠中，与对照组相比，气管和支气管组织提取物中生长抑素水平分别选择性增加了2倍和3倍，但肺组织中未增加。致敏后气管和支气管中生长抑素水平的升高与相应胞质组分中高亲和力和低亲和力结合位点的结合能力降低有关（亲和力值无变化）。这些结果表明，气道生长抑素含量的增加可能参与了过敏性支气管收缩的发病机制。
