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季节性甲型（H3N2）流感病毒预激发对猪源甲型（H3N2）变异株交叉反应性血凝抑制抗体流行率的影响

Effect of Priming With Seasonal Influenza A(H3N2) Virus on the Prevalence of Cross-Reactive Hemagglutination-Inhibition Antibodies to Swine-Origin A(H3N2) Variants.

作者信息

Liu Feng, Veguilla Vic, Gross F Liaini, Gillis Eric, Rowe Thomas, Xu Xiyan, Tumpey Terrence M, Katz Jacqueline M, Levine Min Z, Lu Xiuhua

机构信息

Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.

出版信息

J Infect Dis. 2017 Sep 15;216(suppl_4):S539-S547. doi: 10.1093/infdis/jix093.

DOI:10.1093/infdis/jix093
PMID:28934461
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5795594/
Abstract

BACKGROUND

Recent outbreaks of swine-origin influenza A(H3N2) variant (H3N2v) viruses have raised public health concerns. Previous studies indicated that older children and young adults had the highest levels of hemagglutination-inhibition (HI) antibodies to 2010-2011 H3N2v viruses. However, newly emerging 2013 H3N2v have acquired antigenic mutations in the hemagglutinin at amino acid position 145 (N145K/R). We estimated the levels of serologic cross-reactivity among humans primed with seasonal influenza A(H3N2) (sH3N2), using postinfection ferret antisera. We also explored age-related HI antibody responses to 2012-2013 H3N2v viruses.

METHODS

Human and ferret antisera were tested in HI assays against 1 representative 2012 H3N2v (145N) and 2 2013 H3N2v (145K/R) viruses, together with 9 sH3N2 viruses circulating since 1968.

RESULTS

Low levels of cross-reactivity between the H3N2v and sH3N2 viruses from the 1970s-1990s were observed using postinfection ferret antisera. The overall seroprevalence among the sH3N2-primed population against 2012-2013 H3N2v viruses was >50%, and age-related seroprevalence was observed. Seroprevalence was significantly higher to 2013 H3N2v than to 2012 H3N2v viruses among some children likely to have been primed with A/Sydney/5/97-like (145K) or A/Wuhan/359/95-like viruses (145K).

CONCLUSIONS

A single substitution (N145K/R) was sufficient to affect seropositivity to H3N2v viruses in some individuals. Insight into age-related antibody responses to newly emerging H3N2v viruses is critical for risk assessment and pandemic preparedness.

摘要

背景

近期猪源甲型H3N2变异株（H3N2v）病毒的爆发引发了公众对公共卫生的关注。先前的研究表明，年龄较大的儿童和年轻人对2010 - 2011年H3N2v病毒的血凝抑制（HI）抗体水平最高。然而，新出现的2013年H3N2v在血凝素的第145位氨基酸（N145K/R）处发生了抗原性突变。我们使用感染后雪貂抗血清估计了接种季节性甲型H3N2（sH3N2）的人群中的血清学交叉反应水平。我们还探讨了与年龄相关的对2012 - 2013年H3N2v病毒的HI抗体反应。

方法

在HI试验中，用人和雪貂抗血清检测1株代表性的2012年H3N2v（145N）和2株2013年H3N2v（145K/R）病毒，以及自1968年以来流行的9株sH3N2病毒。

结果

使用感染后雪貂抗血清观察到20世纪70年代至90年代的H3N2v和sH3N2病毒之间的交叉反应水平较低。接种sH3N2的人群对2012 - 2013年H3N2v病毒的总体血清阳性率>50%，且观察到与年龄相关的血清阳性率。在一些可能接种过A/悉尼/5/97样（145K）或A/武汉/359/95样病毒（(145K）的儿童中，对2013年H3N2v病毒的血清阳性率显著高于对2012年H3N2v病毒的血清阳性率。

结论

单个氨基酸替换（N145K/R）足以影响某些个体对H3N2v病毒的血清阳性率。了解与年龄相关的对新出现的H3N2v病毒的抗体反应对于风险评估和大流行防范至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c87a/5795594/927fc5c70077/nihms936846f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c87a/5795594/71500227019b/nihms936846f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c87a/5795594/7f80d46b24c6/nihms936846f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c87a/5795594/927fc5c70077/nihms936846f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c87a/5795594/71500227019b/nihms936846f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c87a/5795594/7f80d46b24c6/nihms936846f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c87a/5795594/927fc5c70077/nihms936846f3.jpg

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