流感雪貂模型中的免疫印记
Immune Imprinting in the Influenza Ferret Model.
作者信息
Skarlupka Amanda L, Ross Ted M
机构信息
Center for Vaccines and Immunology, University of Georgia, Athens, GA 30602, USA.
Department of Infectious Diseases, University of Georgia, Athens, GA 30602, USA.
出版信息
Vaccines (Basel). 2020 Apr 8;8(2):173. doi: 10.3390/vaccines8020173.
Abstract
The initial exposure to influenza virus usually occurs during childhood. This imprinting has long-lasting effects on the immune responses to subsequent infections and vaccinations. Animal models that are used to investigate influenza pathogenesis and vaccination do recapitulate the pre-immune history in the human population. The establishment of influenza pre-immune ferret models is necessary for understanding infection and transmission and for designing efficacious vaccines.
摘要
初次接触流感病毒通常发生在儿童时期。这种印记对后续感染和疫苗接种的免疫反应具有持久影响。用于研究流感发病机制和疫苗接种的动物模型确实再现了人类群体的免疫前史。建立流感免疫前雪貂模型对于理解感染和传播以及设计有效的疫苗是必要的。
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