University of Alberta, Alberta, Canada.
University of Alberta, Alberta, Canada.
Eur J Cell Biol. 2017 Oct;96(7):643-652. doi: 10.1016/j.ejcb.2017.09.001. Epub 2017 Sep 6.
Constructing the distinct subcellular environment of the cilium relies in a large part upon intraflagellar transport (IFT) proteins, which traffic cargo both to and within the cilium. However, evidence from the last 10 years suggests that IFT alone is not sufficient to generate the ciliary environment. One essential factor is UNC119, which interacts with known IFT molecular switches to transport ciliary cargos. Despite its apparent importance in ciliary trafficking though, human UNC119 mutations have only rarely been associated with diseases commonly linked with ciliopathies. This review will outline the trafficking pathways required for constructing the cilium by highlighting UNC119's role and the complexities involved in ciliary trafficking. Finally, despite important roles for UNC119 in cilia, UNC119 proteins also interact with non-ciliary proteins to affect other cellular processes.
构建纤毛独特的亚细胞环境在很大程度上依赖于鞭毛内运输（IFT）蛋白，这些蛋白将货物运输到纤毛内外。然而，过去 10 年的证据表明，IFT 本身不足以产生纤毛环境。一个重要因素是 UNC119，它与已知的 IFT 分子开关相互作用，以运输纤毛货物。尽管 UNC119 在纤毛运输中显然很重要，但人类 UNC119 突变很少与通常与纤毛病相关的疾病有关。这篇综述将通过突出 UNC119 的作用以及纤毛运输中涉及的复杂性，概述构建纤毛所需的运输途径。最后，尽管 UNC119 在纤毛中具有重要作用，但 UNC119 蛋白也与非纤毛蛋白相互作用，影响其他细胞过程。
