JSS College of Pharmacy, Ootacamund, Jagadguru Sri Shivarathreeshwara University, Mysuru, Karnataka, India.
JSS College of Pharmacy, Ootacamund, Jagadguru Sri Shivarathreeshwara University, Mysuru, Karnataka, India.
Int J Biol Macromol. 2018 Feb;107(Pt A):906-919. doi: 10.1016/j.ijbiomac.2017.09.059. Epub 2017 Sep 19.
Breast cancer is one of the leading reasons for the morbidity and mortality of cancer related death globally. The modern therapies are basically the combination of the breast-preserving surgeries or ablation with or without node biopsy or destroying the carcinoma cells adjuvant with chemotherapy, radiotherapy, hormonal or biological therapies depending upon the nature of the receptor of the cancerous cells, nature of the lymph node, as well as the tendency of the recurrence. For decade's carcinoma management suffered by the limitation of imagining, targeting and penetrability problem associated with management and cure of this deadly disease leads to unwanted chemo-toxicity and side effects. Alike other antibody mimetics, affibodies are designed with the combinatorial protein engineering approaches which are small and robust protein scaffolds retaining the favorable folding and stability. Affibody is one of the significantly important tools for imaging and diagnosis of the affinity specific over expressed proteins in the breast cancer management. The review summarizes the various affibody strategies uses in the management of breast cancer.
乳腺癌是全球癌症相关死亡发病率和死亡率的主要原因之一。现代疗法基本上是保乳手术或消融术的结合，辅以或不辅以淋巴结活检，或辅以化疗、放疗、激素或生物疗法来破坏癌性细胞，这取决于癌细胞受体的性质、淋巴结的性质以及复发的趋势。几十年来，由于成像、靶向和穿透性问题的限制，癌症管理在治疗这种致命疾病方面受到限制，导致不必要的化疗毒性和副作用。与其他抗体模拟物一样，亲和体是通过组合蛋白工程方法设计的，它们是小型且坚固的蛋白支架，保留了有利的折叠和稳定性。亲和体是用于乳腺癌管理中过表达蛋白的成像和诊断的重要工具之一。本文综述了在乳腺癌管理中使用的各种亲和体策略。
