-308 G>A（rs1800629）基因多态性对麻风病风险调节的影响：14 项病例对照研究的再评价荟萃分析。

Impact of -308 G>A (rs1800629) gene polymorphism in modulation of leprosy risk: a reappraise meta-analysis of 14 case-control studies.

机构信息

Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan 45142, Saudi Arabia.

The University College of Medical Sciences and GTB Hospital, University of Delhi, Delhi 110095, India.

出版信息

Biosci Rep. 2017 Oct 27;37(5). doi: 10.1042/BSR20170806. Print 2017 Oct 31.

DOI:10.1042/BSR20170806

PMID:28935761

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5664359/

Abstract

PURPOSE

Earlier studies have shown that tumor necrosis factor () -308 G>A (rs1800629) gene polymorphism is implicated in the susceptibility to leprosy, but results were inconsistent.

METHODS

A meta-analysis of 14 studies involving 3327 leprosy cases and 3203 controls was performed to appraise the association of -308 G>A polymorphism with leprosy using MEDLINE (PUBMED), EMBASE, and Google Scholar web databases.

RESULTS

Overall, no significant association was observed in allelic (A vs. G: =0.068; OR = 0.836, 95% CI = 0.689-1.013), homozygous (AA vs. GG: =0.394; OR = 0.810, 95% CI = 0.499-1.315), heterozygous (GA vs. GG: =0.059; OR = 0.780, 95% CI = 0.603-1.010), dominant (AA + GA vs. GG: =0.067; OR = 0.797, 95% CI = 0.625-1.016), and recessive (AA vs. GG + GA: =0.594; OR = 0.877, 95% CI = 0.542- 1.420) genetic models. Subgroup analysis showed no association in Asians. Whereas, reduced risk was found in allelic contrast (A vs. G: =0.014; OR = 0.832, 95% CI = 0.718-0.963) and dominant models (AA + GA vs. GG: =0.004; OR = 0.790, 95% CI = 0.673-0.928) of the mixed population.

CONCLUSIONS

-308 G>A polymorphism is not associated with leprosy risk in the overall population. However, subgroup analysis demonstrated protective effect of the said polymorphism in leprosy risk in the Latin American population, but showed no association in the Asians.

摘要

目的

早期研究表明，肿瘤坏死因子（TNF）-308 G＞A（rs1800629）基因多态性与麻风病易感性有关，但结果不一致。

方法

对 14 项研究进行了荟萃分析，共涉及 3327 例麻风病病例和 3203 例对照，使用 MEDLINE（PUBMED）、EMBASE 和 Google Scholar 网络数据库评估-308 G＞A 多态性与麻风病的关系。

结果

总体而言，等位基因（A 对 G：=0.068；OR=0.836，95%CI=0.689-1.013）、纯合子（AA 对 GG：=0.394；OR=0.810，95%CI=0.499-1.315）、杂合子（GA 对 GG：=0.059；OR=0.780，95%CI=0.603-1.010）、显性（AA+GA 对 GG：=0.067；OR=0.797，95%CI=0.625-1.016）和隐性（AA 对 GG+GA：=0.594；OR=0.877，95%CI=0.542-1.420）遗传模型均未显示出相关性。亚组分析显示亚洲人群无相关性。然而，在混合人群中，等位基因对比（A 对 G：=0.014；OR=0.832，95%CI=0.718-0.963）和显性模型（AA+GA 对 GG：=0.004；OR=0.790，95%CI=0.673-0.928）中发现风险降低。