Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia; and.
Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia.
J Nucl Med. 2018 Feb;59(2):315-319. doi: 10.2967/jnumed.117.196915. Epub 2017 Sep 21.
The aim of this study was to measure the test-retest reliability of C--dimethyl-2-(2'-amino-4'-hydroxymethylphenylthio)benzylamine (C-HOMADAM) imaging of serotonin transporter (SERT) density in healthy control subjects. Two female and 2 male volunteers participated in the study, with each undergoing three 90-min C-HOMADAM PET scans. Time-activity curves were derived from SERT-rich structures and fit to 2 models: a simplified reference tissue model and a multilinear graphical model. Binding potential, the ratio of specifically bound uptake to nondisplaceable uptake at equilibrium, was calculated from the model parameter estimates. Ninety-five percent confidence intervals and the intraclass correlation coefficient (ICC) were calculated and adjusted for repeated measures. The ICC values ranged from -0.13 in the dorsal raphe to 0.88 in the caudate nucleus. The highest average ICC values were in the striatum, but other regions were sensitive to measurement outliers. Good-to-excellent test-retest reliability was observed for SERT binding in the striatum. The dorsal raphe ICC value was sensitive to a measurement outlier. C-HOMADAM binding potential calculated from the simplified reference tissue model and the multilinear graphical model were robust and in good agreement.
本研究旨在测量健康对照者中 C--二甲基-2-(2'-氨基-4'-羟甲基苯硫基)苄基胺（C-HOMADAM）对血清素转运体（SERT）密度的再测试可靠性。两名女性和两名男性志愿者参加了这项研究，他们每个人都接受了三次 90 分钟的 C-HOMADAM PET 扫描。从 SERT 丰富的结构中得出时间活性曲线，并拟合到 2 个模型：简化参考组织模型和多线性图形模型。从模型参数估计中计算出结合势，即平衡时特异性结合摄取与不可置换摄取的比率。计算了 95％置信区间和组内相关系数（ICC），并对重复测量进行了调整。ICC 值范围从背缝核的-0.13 到尾状核的 0.88。纹状体的平均 ICC 值最高，但其他区域对测量异常值敏感。纹状体中 SERT 结合的再测试可靠性良好至优秀。背缝核的 ICC 值对测量异常值敏感。简化参考组织模型和多线性图形模型计算的 C-HOMADAM 结合势具有稳健性且一致性良好。
