Department of Physics, Stockholm University, SE-10691, Stockholm, Sweden.
SCA R&D Centre, Sidsjövägen 2, SE-85121, Sundsvall, Sweden.
J Am Soc Mass Spectrom. 2017 Dec;28(12):2686-2691. doi: 10.1007/s13361-017-1796-7. Epub 2017 Sep 21.
Here we report on the gas-phase interactions between protonated enantiopure amino acids (L- and D-enantiomers of Met, Phe, and Trp) and chiral target gases [(R)- and (S)-2-butanol, and (S)-1-phenylethanol] in 0.1-10.0 eV low-energy collisions. Two major processes are seen to occur over this collision energy regime, collision-induced dissociation and ion-molecule complex formation. Both processes were found to be independent of the stereo-chemical composition of the interacting ions and targets. These data shed light on the currently debated mechanisms of gas-phase chiral selectivity by demonstrating the inapplicability of the three-point model to these interactions, at least under single collision conditions. Graphical Abstract.
在这里，我们报告了在 0.1-10.0 eV 低能碰撞中，质子化的对映纯氨基酸（Met、Phe 和 Trp 的 L-和 D-对映体）与手性靶气体[（R）-和（S）-2-丁醇和（S）-1-苯乙醇]之间的气相相互作用。在这个碰撞能区观察到两种主要的过程，即碰撞诱导解离和离子-分子复合物形成。这两种过程都被发现与相互作用的离子和靶标在立体化学组成上无关。这些数据通过证明三点模型不适用于这些相互作用，至少在单次碰撞条件下，揭示了气相手性选择性的当前有争议的机制，为这些数据提供了依据。
