手性识别和质谱法测定对映体过量：综述。
Chiral recognition and determination of enantiomeric excess by mass spectrometry: A review.
机构信息
College of Pharmacy, Jinan University, Guangzhou 510632, Guangdong, China; State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation) and Shenzhen Key Laboratory of Food Biological Safety Control, Shenzhen Research Institute of Hong Kong Polytechnic University, Shenzhen 518057, China.
State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation) and Shenzhen Key Laboratory of Food Biological Safety Control, Shenzhen Research Institute of Hong Kong Polytechnic University, Shenzhen 518057, China; Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules (Yanbian University), Ministry of Education, Yanji 133002, Jilin, China; State Key Laboratory of Chirosciences, Food Safety and Technology Research Centre and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong Special Administrative Region, China.
出版信息
Anal Chim Acta. 2017 May 22;968:1-20. doi: 10.1016/j.aca.2017.03.021. Epub 2017 Mar 22.
Chiral analysis is of great importance to fundamental and applied research in chemical, biological and pharmaceutical sciences. Due to the superiority of mass spectrometry (MS) over other analytical methods in terms of speed, specificity and sensitivity, chiral analysis by MS has attracted much interest in recent years. Chiral analysis by MS typically involves introduction of a chiral selector to form diastereomers with analyte enantiomers, and comparison of the behaviors of diastereomers in MS. Chiral differentiation can be achieved by comparing the relative abundances of diastereomers, the thermodynamic or kinetic constants of ion-molecule reactions of diastereomers in the gas phase, the dissociation of diastereomers in MS/MS, or the mobility of diastereomers in ion mobility mass spectrometry. In this review, chiral recognition and determination of enantiomeric excess by these chiral MS methods were summarized, and the prospects of chiral analysis by MS were discussed.
手性分析对于化学、生物和制药科学中的基础研究和应用研究非常重要。由于质谱 (MS) 在速度、特异性和灵敏度方面优于其他分析方法，因此近年来，通过 MS 进行手性分析引起了广泛关注。MS 进行手性分析通常涉及引入手性选择剂与分析物对映异构体形成非对映异构体，然后比较非对映异构体在 MS 中的行为。通过比较非对映异构体的相对丰度、气相中非对映异构体离子-分子反应的热力学或动力学常数、MS/MS 中非对映异构体的解离或离子淌度质谱中非对映异构体的迁移率，可以实现手性区分。在这篇综述中，总结了这些手性 MS 方法对手性识别和对映体过量的测定，并讨论了 MS 进行手性分析的前景。
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