长效生长抑素类似物SMS 201-995预防胰腺微腺瘤病患者低血糖症

Prevention of hypoglycaemia in a patient with pancreatic microadenomatosis by a long-acting somatostatin analogue SMS 201-995.

作者信息

Kung A W, Ma J T, Wang C, Fu K H, Lam K S, Yeung R T, Boey J

机构信息

Department of Medicine, Queen Mary Hospital, University of Hong Kong.

出版信息

Clin Endocrinol (Oxf). 1987 Oct;27(4):469-73. doi: 10.1111/j.1365-2265.1987.tb01175.x.

DOI:10.1111/j.1365-2265.1987.tb01175.x

PMID:2893673

Abstract

Acute suppression of insulin secretion from pancreatic insulinomas by long-acting somatostatin analogue SMS 201-995 has been documented. We report the chronic use of the drug in a patient with persistent hypoglycaemia due to benign pancreatic microadenomatosis with satisfactory control of plasma glucose level and reduction of insulin production. There was no tachyphylaxis or untoward side-effect noted during the 6-month treatment period.

摘要

长效生长抑素类似物SMS 201-995对胰腺胰岛素瘤胰岛素分泌的急性抑制作用已有文献记载。我们报告了一名因良性胰腺微腺瘤病导致持续性低血糖的患者长期使用该药物的情况，其血糖水平得到了满意控制，胰岛素分泌减少。在6个月的治疗期间，未观察到快速耐受性或不良副作用。