Al Salmi Issa, Metry Abdul Massiah, Al Ismaili Faisal, Hola Alan, Shaheen Faissal, Fakhoury Hana, Hannawi Suad
Department of Renal Medicine, The Royal Hospital, Muscat, Oman.
The Saudi Center for Organ Transplantation, Riyadh, Saudi Arabia.
Saudi J Kidney Dis Transpl. 2017 Sep-Oct;28(5):1021-1026. doi: 10.4103/1319-2442.215135.
Oman is located on the Southeastern coast of the Arabian Peninsula, and its population has high levels of consanguinity. Human leukocytic antigen (HLA) typing analysis in human population holds unexploited potential for elucidating the genetic causes of human disease and possibly leads to personalized medicine. This is a retrospective, descriptive study evaluating HLA frequencies of Omani individuals who underwent workup for kidney transplantation at the Royal Hospital (RH) from 2005 to 2016. Data on 870 subjects were collected from the Oman kidney transplant registry at RH as well from electronic medical record system. The mean age (standard deviation) years for the cohort were 33.2 (13.0). Males constituted 56.3% (490) while females constituted 43.7% (380). Seven HLA-A alleles accounted for more than 70% of the total alleles. Of which, HLA-A2 contributed the highest frequency (24%), followed by HLA A11 (9.4%), and A32 (8.1%). Ten alleles accounted for 70% of HLA-B alleles. Of which, HLA-B51 was the most common (18.9%), followed by HLA-B-35 (13.6%), and HLA-B8 (7.9%). Seven HLA-DRB1 alleles accounted for more than 70% of the total HLA DRB1 alleles, of which HLA- DRB116 contributed the highest frequency (29.56%). This was followed by HLA-DRB103 (14.57%) and HLA-DRB111 (9.48%). While three alleles accounted for more than 75% of the total HLA DQB1alleles. Of which, HLA-DQB105 contributed the highest frequency (37.56%). This was followed by allele HLA-DQB102 (26.48%) and HLA-DQB103 (17.18%). This study showed considerable heterogeneity in both HLA Class I and Class II antigens, which reflects admixture of our population with rest of old world countries. Despite the high levels of consanguinity, this population is genetically highly heterogeneous. These findings may be useful for transplantation programs, noncommunicable diseases, epidemiology of HLA linked diseases, pharmacogenomics, and anthropology.
阿曼位于阿拉伯半岛的东南海岸，其人口近亲结婚率很高。对人类群体进行人类白细胞抗原（HLA）分型分析在阐明人类疾病的遗传原因方面具有尚未开发的潜力，并可能导向个性化医疗。这是一项回顾性描述性研究，评估了2005年至2016年期间在皇家医院（RH）接受肾脏移植检查的阿曼人的HLA频率。从RH的阿曼肾脏移植登记处以及电子病历系统收集了870名受试者的数据。该队列的平均年龄（标准差）为33.2（13.0）岁。男性占56.3%（490人），女性占43.7%（380人）。7个HLA - A等位基因占总等位基因的70%以上。其中，HLA - A2的频率最高（24%），其次是HLA A11（9.4%）和A32（8.1%）。10个等位基因占HLA - B等位基因的70%。其中，HLA - B51最常见（18.9%），其次是HLA - B - 35（13.6%）和HLA - B8（7.9%）。7个HLA - DRB1等位基因占总HLA DRB1等位基因的70%以上，其中HLA - DRB116的频率最高（29.56%）。其次是HLA - DRB103（14.57%）和HLA - DRB111（9.48%）。而3个等位基因占总HLA DQB1等位基因的75%以上。其中，HLA - DQB105的频率最高（37.56%）。其次是等位基因HLA - DQB102（26.48%）和HLA - DQB103（17.18%）。这项研究表明，HLA I类和II类抗原均存在相当大的异质性，这反映了我们的人群与其他旧世界国家人群的混合情况。尽管近亲结婚率很高，但该人群在基因上高度异质。这些发现可能对移植项目、非传染性疾病、HLA相关疾病的流行病学、药物基因组学和人类学有用。
