Laszlo R, Konz H, Kunz K, Dallmeier D, Klenk J, Denkinger M, Koenig W, Rothenbacher D, Steinacker For The ActiFE Study Group J M
Division of Sports and Rehabilitation Medicine, Ulm University, Ulm, Germany.
Physiol Res. 2017 Dec 20;66(6):933-948. doi: 10.33549/physiolres.933453. Epub 2017 Sep 22.
It is unknown whether physiological ageing also goes along with electromechanical asynchrony of contraction. Aim of the study was to evaluate synchrony of contraction in older people with ("non-healthy") or without ("healthy") evidence for structural cardiac disease. In 547 persons (age 76.7+/-5.5 years, 306 male, 241 female) recruited from a population-based cohort of the ActiFE-Ulm study including a random sample of people >/=65 years old living in the region of Ulm, Germany, various PW- and TDI-Doppler based markers for asynchrony were obtained by echocardiography. Within a subgroup of 84 healthy subjects, at most minimal systolic and diastolic asynchrony was found. Concerning systolic asynchrony, similar observations were made within the non-healthy subgroup. However, extent of diastolic left ventricular intraventricular asynchrony and also - by tendency - diastolic interventricular asynchrony was increased in comparison to the healthy subgroup. To conclude, no evidence that physiological ageing might go along with relevant left or right ventricular systolic or diastolic electromechanical asynchrony was found in our study. Furthermore, our population-based data support the results from other clinical studies with rather selected cohorts that structural heart diseases might go along with increased diastolic asynchrony.
生理衰老是否也伴随着收缩的机电不同步尚不清楚。本研究的目的是评估有（“不健康”）或无（“健康”）结构性心脏病证据的老年人的收缩同步性。在从基于人群的ActiFE-乌尔姆研究队列中招募的547人（年龄76.7±5.5岁，男性306人，女性241人）中，该队列包括德国乌尔姆地区≥65岁人群的随机样本，通过超声心动图获得了各种基于PW和TDI多普勒的不同步标记物。在84名健康受试者的亚组中，发现至多有最小的收缩期和舒张期不同步。关于收缩期不同步，在不健康亚组中也有类似的观察结果。然而，与健康亚组相比，舒张期左心室内不同步的程度以及舒张期心室间不同步的程度（也有一定趋势）有所增加。总之，在我们的研究中，没有发现生理衰老可能伴随着相关的左或右心室收缩期或舒张期机电不同步的证据。此外，我们基于人群的数据支持了其他针对特定队列的临床研究结果，即结构性心脏病可能伴随着舒张期不同步的增加。
