Department of Veterinary Medicine, National Taiwan University, Taipei 10617, Taiwan.
Research Center for Nanotechnology and Infectious Diseases, Taipei 11529, Taiwan.
Int J Mol Sci. 2017 Sep 22;18(10):2030. doi: 10.3390/ijms18102030.
Infectious bronchitis virus (IBV) variants constantly emerge and pose economic threats to poultry farms worldwide. Numerous studies on the molecular and pathogenic characterization of IBV variants have been performed between 2007 and 2017, which we have reviewed herein. We noted that viral genetic mutations and recombination events commonly gave rise to distinct IBV genotypes, serotypes and pathotypes. In addition to characterizing the genes, full viral genomic sequencing, comprehensive antigenicity, and pathogenicity studies on emerging variants have advanced our understanding of IBV infections, which is valuable for developing countermeasures against IBV field outbreaks. This review of IBV variants provides practical value for understanding their phylogenetic relationships and epidemiology from both regional and worldwide viewpoints.
传染性支气管炎病毒（IBV）变异株不断出现，给全球家禽养殖场带来经济威胁。我们对 2007 年至 2017 年间关于 IBV 变异株的分子和致病性特征的大量研究进行了综述。我们注意到，病毒遗传突变和重组事件通常导致不同的 IBV 基因型、血清型和病原型。除了对基因进行特征描述外，对新兴变异株的全病毒基因组测序、全面的抗原性和致病性研究，加深了我们对 IBV 感染的认识，这对于开发针对 IBV 田间暴发的对策具有重要价值。本综述对 IBV 变异株的研究，为从区域和全球角度理解其系统发生关系和流行病学提供了实用价值。
