CT引导下碘-125粒子植入治疗复发性卵巢癌。
CT-guided I brachytherapy for recurrent ovarian cancer.
作者信息
Liu Ping, Tong Lina, Huo Bin, Dai Dong, Liu Wenxin, Wang Ke, Wang Ying, Guo Zhi, Ni Hong
机构信息
Department of Interventional Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, People's Republic of China.
Department of Oncology, The Second Hospital of Tianjin Medical University, Tianjin, People's Republic of China.
出版信息
Oncotarget. 2017 Mar 4;8(35):59766-59776. doi: 10.18632/oncotarget.15905. eCollection 2017 Aug 29.
This retrospective study was to evaluate the local control and survival of I brachytherapy for recurrent ovarian cancer. 52 I brachytherapy procedures were performed in 47 patients with 51 recurrent ovarian cancer lesions. The follow-up period was 1-55 months (median 12 months). The local control rate (LC) of 3, 6, 12, 24 and 36 months was 93.3%, 77.7%, 58.9%, 38.7% and 19.3%, respectively. Patients with tumor size ≤ 4cm (85.7% vs 40.0%, = 0.037) and actual D90 between 110 to 130Gy (47.4% vs 66.7% vs 62.5%, = 0.029) had better LC. The 1, 2 and 3 years of overall survival (OS) was 79.3%, 63.0% and 52.5%, respectively. The poor performance status (HR 3.821, 95% CI 1.383-10.555; = 0.010), concurrent distant metastasis (HR 9.222, 95% CI 1.710-49.737; = 0.010) and large postoperative residual tumor size (HR 6.157, 95% CI 1.438-26.367; = 0.014) were closely correlated with a poor OS. Our data indicate thatCT-guided I brachytherapy is an effective and safe modality for the local treatment of recurrent ovarian cancer.
本回顾性研究旨在评估 I 型近距离放射治疗复发性卵巢癌的局部控制率和生存率。对 47 例患者的 51 个复发性卵巢癌病灶进行了 52 次 I 型近距离放射治疗。随访期为 1 - 55 个月（中位时间 12 个月）。3、6、12、24 和 36 个月时的局部控制率（LC）分别为 93.3%、77.7%、58.9%、38.7%和 19.3%。肿瘤大小≤4cm（85.7%对 40.0%，P = 0.037）以及实际 D90 在 110 至 130Gy 之间（47.4%对 66.7%对 62.5%，P = 0.029）的患者局部控制率更好。1、2 和 3 年的总生存率（OS）分别为 79.3%、63.0%和 52.5%。较差的体能状态（HR 3.821，95%CI 1.383 - 10.555；P = 0.010）、并发远处转移（HR 9.222，95%CI 1.710 - 49.737；P = 0.010）以及术后残留肿瘤较大（HR 6.157，95%CI 1.438 - 26.367；P = 0.014）与较差的总生存率密切相关。我们的数据表明，CT 引导下的 I 型近距离放射治疗是局部治疗复发性卵巢癌的一种有效且安全的方式。
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